Mechanical properties and degradation behaviors of hyaluronic acid hydrogels cross-linked at various cross-linking densities

Oju Jeon, Su Jin Song, Kee Jung Lee, Moon Hyang Park, Soo Hong Lee, Sei Kwang Hahn, Sungjee Kim, Byung Soo Kim

Research output: Contribution to journalArticlepeer-review

184 Scopus citations

Abstract

The effect of cross-linking density of hyaluronic acid (HA) hydrogels on mechanical properties and degradation behaviors has been investigated. HA hydrogels were prepared by the covalent cross-linking of HA with poly(ethylene glycol)-diamine with two different molecular weights at various cross-linking densities. The elastic modulus increased gradually as the theoretical cross-linking density of HA hydrogels increased from 0% to 20%. However, as the theoretical cross-linking density increased above 20%, the elastic modulus decreased. At a theoretical cross-linking density of 20%, the elastic modulus increased as the molecular weight of the cross-linking molecule decreased. In vitro degradation rates of HA hydrogels decreased as the molecular weight of the cross-linking molecule decreased at a theoretical cross-linking density of 20%. The degradation rate of the cross-linked HA hydrogels decreased with increases in the theoretical cross-linking density from 0% to 20%. However, there was no significant difference in the degradation rate as the theoretical cross-linking density increased above 30%. With controllable mechanical properties and degradation rates, the developed HA hydrogels would be further investigated for various medical applications.

Original languageEnglish
Pages (from-to)251-257
Number of pages7
JournalCarbohydrate Polymers
Volume70
Issue number3
DOIs
StatePublished - 1 Oct 2007

Keywords

  • Cross-linking
  • Degradation
  • Elastic modulus
  • Hyaluronic acid
  • Hydrogel
  • Poly(ethylene glycol)

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