Medical Manuscript: Serum Total Testosterone as a Prognostic Indicator in Male Patients With Terminal Cancer

Se Won Kim; In Cheol Hwang; Hee Kyung Ahn; Sun Young Kyung; Hong Yup Ahn

doi:10.1177/1049909115574492

Medical Manuscript: Serum Total Testosterone as a Prognostic Indicator in Male Patients With Terminal Cancer

Se Won Kim
, In Cheol Hwang
, Hee Kyung Ahn
, Sun Young Kyung
, Hong Yup Ahn

Department of Statistics

Gachon University

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The role of total serum testosterone in the prognosis of terminal cancer is unclear. We retrospectively investigated the total serum testosterone level in 69 male patients with terminal cancer in a palliative care unit. The association between the serum testosterone level and survival was assessed using Cox proportional hazard model. The median value of serum total testosterone was 44.5 ng/dL, far lower than previously reported in patients with advanced cancer. Multivariate analysis revealed thrombocytopenia (adjusted hazard ratio [aHR], 2.68), hypoalbuminemia (aHR, 2.02), azotemia (aHR, 2.67), and lower serum testosterone level (aHR, 2.03) were significantly negatively prognostic of survival. Lower serum testosterone level was an independent unfavorable prognostic factor for life expectancy in male patients with terminal cancer.

Original language	English
Pages (from-to)	483-488
Number of pages	6
Journal	American Journal of Hospice and Palliative Medicine
Volume	33
Issue number	5
DOIs	https://doi.org/10.1177/1049909115574492
State	Published - Jun 2016

Keywords

palliative care
prognostication
serum testosterone

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/1049909115574492

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title = "Medical Manuscript: Serum Total Testosterone as a Prognostic Indicator in Male Patients With Terminal Cancer",

abstract = "The role of total serum testosterone in the prognosis of terminal cancer is unclear. We retrospectively investigated the total serum testosterone level in 69 male patients with terminal cancer in a palliative care unit. The association between the serum testosterone level and survival was assessed using Cox proportional hazard model. The median value of serum total testosterone was 44.5 ng/dL, far lower than previously reported in patients with advanced cancer. Multivariate analysis revealed thrombocytopenia (adjusted hazard ratio [aHR], 2.68), hypoalbuminemia (aHR, 2.02), azotemia (aHR, 2.67), and lower serum testosterone level (aHR, 2.03) were significantly negatively prognostic of survival. Lower serum testosterone level was an independent unfavorable prognostic factor for life expectancy in male patients with terminal cancer.",

keywords = "palliative care, prognostication, serum testosterone",

author = "Kim, \{Se Won\} and Hwang, \{In Cheol\} and Ahn, \{Hee Kyung\} and Kyung, \{Sun Young\} and Ahn, \{Hong Yup\}",

note = "Publisher Copyright: {\textcopyright} 2015, {\textcopyright} The Author(s) 2015.",

year = "2016",

month = jun,

doi = "10.1177/1049909115574492",

language = "English",

volume = "33",

pages = "483--488",

journal = "American Journal of Hospice and Palliative Medicine",

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}

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T1 - Medical Manuscript

T2 - Serum Total Testosterone as a Prognostic Indicator in Male Patients With Terminal Cancer

AU - Kim, Se Won

AU - Hwang, In Cheol

AU - Ahn, Hee Kyung

AU - Kyung, Sun Young

AU - Ahn, Hong Yup

PY - 2016/6

Y1 - 2016/6

N2 - The role of total serum testosterone in the prognosis of terminal cancer is unclear. We retrospectively investigated the total serum testosterone level in 69 male patients with terminal cancer in a palliative care unit. The association between the serum testosterone level and survival was assessed using Cox proportional hazard model. The median value of serum total testosterone was 44.5 ng/dL, far lower than previously reported in patients with advanced cancer. Multivariate analysis revealed thrombocytopenia (adjusted hazard ratio [aHR], 2.68), hypoalbuminemia (aHR, 2.02), azotemia (aHR, 2.67), and lower serum testosterone level (aHR, 2.03) were significantly negatively prognostic of survival. Lower serum testosterone level was an independent unfavorable prognostic factor for life expectancy in male patients with terminal cancer.

AB - The role of total serum testosterone in the prognosis of terminal cancer is unclear. We retrospectively investigated the total serum testosterone level in 69 male patients with terminal cancer in a palliative care unit. The association between the serum testosterone level and survival was assessed using Cox proportional hazard model. The median value of serum total testosterone was 44.5 ng/dL, far lower than previously reported in patients with advanced cancer. Multivariate analysis revealed thrombocytopenia (adjusted hazard ratio [aHR], 2.68), hypoalbuminemia (aHR, 2.02), azotemia (aHR, 2.67), and lower serum testosterone level (aHR, 2.03) were significantly negatively prognostic of survival. Lower serum testosterone level was an independent unfavorable prognostic factor for life expectancy in male patients with terminal cancer.

KW - palliative care

KW - prognostication

KW - serum testosterone

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DO - 10.1177/1049909115574492

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C2 - 25712105

AN - SCOPUS:84964941495

SN - 1049-9091

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SP - 483

EP - 488

JO - American Journal of Hospice and Palliative Medicine

JF - American Journal of Hospice and Palliative Medicine

IS - 5

ER -

Medical Manuscript: Serum Total Testosterone as a Prognostic Indicator in Male Patients With Terminal Cancer

Abstract

Keywords

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