Medullary thyroid carcinoma: A 30-year experience at one institution in Korea

Cho Rok Lee, Sohee Lee, Haiyoung Son, Eunjeong Ban, Sang Wook Kang, Jandee Lee, Jong Ju Jeong, Kee Hyun Nam, Woong Youn Chung, Cheong Soo Park

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Purpose: The objective of this study was to review the clinical outcome and prognosis of patients with sporadic and hereditary medullary thyroid cancer (MTC) who were treated at a single tertiary hospital in Korea. Methods: We retrospectively reviewed the case files of 85 patients treated from August 1982 to February 2012. Results: In all, 65 patients (76.5%) had sporadic MTC and 20 patients (23.5%) had hereditary MTC. Patients in the sporadic group were older than in the hereditary group (P < 0.001). However, the hereditary group had more tumor multiplicity (P < 0.001) and bilaterality (P < 0.001). Neither survival rate was significantly different between the sporadic and hereditary groups (P = 0.775 and P = 0.866). By multivariate analysis, distant metastasis was a significant prognostic factor for overall and progression-free survival. Conclusion: In general, patients with MTC have favorable outcomes. Distant metastasis appears to be the strongest predictor of overall and progression-free survival.

Original languageEnglish
Pages (from-to)278-287
Number of pages10
JournalAnnals of Surgical Treatment and Research
Volume91
Issue number6
DOIs
StatePublished - Dec 2016

Keywords

  • Familial medullary thyroid carcinoma
  • Prognosis
  • Survival

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