Abstract
Purpose: The objective of this study was to review the clinical outcome and prognosis of patients with sporadic and hereditary medullary thyroid cancer (MTC) who were treated at a single tertiary hospital in Korea. Methods: We retrospectively reviewed the case files of 85 patients treated from August 1982 to February 2012. Results: In all, 65 patients (76.5%) had sporadic MTC and 20 patients (23.5%) had hereditary MTC. Patients in the sporadic group were older than in the hereditary group (P < 0.001). However, the hereditary group had more tumor multiplicity (P < 0.001) and bilaterality (P < 0.001). Neither survival rate was significantly different between the sporadic and hereditary groups (P = 0.775 and P = 0.866). By multivariate analysis, distant metastasis was a significant prognostic factor for overall and progression-free survival. Conclusion: In general, patients with MTC have favorable outcomes. Distant metastasis appears to be the strongest predictor of overall and progression-free survival.
Original language | English |
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Pages (from-to) | 278-287 |
Number of pages | 10 |
Journal | Annals of Surgical Treatment and Research |
Volume | 91 |
Issue number | 6 |
DOIs | |
State | Published - Dec 2016 |
Keywords
- Familial medullary thyroid carcinoma
- Prognosis
- Survival