TY - JOUR
T1 - Meta-analysis for genome-wide association studies using case-control design
T2 - application and practice
AU - Shim, Sungryul
AU - Kim, Jiyoung
AU - Jung, Wonguen
AU - Shin, In Soo
AU - Bae, Jong Myon
PY - 2016
Y1 - 2016
N2 - This review aimed to arrange the process of a systematic review of genome-wide association studies in order to practice and apply a genome-wide meta-analysis (GWMA). The process has a series of five steps: searching and selection, extraction of related information, evaluation of validity, meta-analysis by type of genetic model, and evaluation of heterogeneity. In contrast to intervention meta-analyses, GWMA has to evaluate the Hardy-Weinberg equilibrium (HWE) in the third step and conduct meta-analyses by five potential genetic models, including dominant, recessive, homozygote contrast, heterozygote contrast, and allelic contrast in the fourth step. The 'genhwcci' and 'metan' commands of STATA software evaluate the HWE and calculate a summary effect size, respectively. A meta-regression using the 'metareg' command of STATA should be conducted to evaluate related factors of heterogeneities.
AB - This review aimed to arrange the process of a systematic review of genome-wide association studies in order to practice and apply a genome-wide meta-analysis (GWMA). The process has a series of five steps: searching and selection, extraction of related information, evaluation of validity, meta-analysis by type of genetic model, and evaluation of heterogeneity. In contrast to intervention meta-analyses, GWMA has to evaluate the Hardy-Weinberg equilibrium (HWE) in the third step and conduct meta-analyses by five potential genetic models, including dominant, recessive, homozygote contrast, heterozygote contrast, and allelic contrast in the fourth step. The 'genhwcci' and 'metan' commands of STATA software evaluate the HWE and calculate a summary effect size, respectively. A meta-regression using the 'metareg' command of STATA should be conducted to evaluate related factors of heterogeneities.
KW - Genetic models
KW - Genome-wide association study
KW - Meta-analysis
KW - Polymorphism
KW - Reviews
UR - http://www.scopus.com/inward/record.url?scp=85015580487&partnerID=8YFLogxK
U2 - 10.4178/epih.e2016058
DO - 10.4178/epih.e2016058
M3 - Article
C2 - 28092928
AN - SCOPUS:85015580487
SN - 2092-7193
VL - 38
SP - e2016058
JO - Epidemiology and health
JF - Epidemiology and health
ER -