Microenvironmental regulation of stem cell behavior through biochemical and biophysical stimulation

Bogyu Choi, Deogil Kim, Inbo Han, Soo Hong Lee

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

8 Scopus citations

Abstract

Stem cells proliferate by undergoing self-renewal and differentiate into multiple cell lineages in response to biochemical and biophysical stimuli. Various biochemical cues such as growth factors, nucleic acids, chemical reagents, and small molecules have been used to induce stem cell differentiation or reprogramming or to maintain their pluripotency. Moreover, biophysical cues such as matrix stiffness, substrate topography, and external stress and strain play a major role in modulating stem cell behavior. In this chapter, we have summarized microenvironmental regulation of stem cell behavior through biochemical and biophysical stimulation.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages147-160
Number of pages14
DOIs
StatePublished - 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1064
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Biochemical cues
  • Biophysical cues
  • Differentiation
  • Reprogramming
  • Stem cells

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