Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids

Hongwon Kim, Hyeok Ju Park, Hwan Choi, Yujung Chang, Hanseul Park, Jaein Shin, Junyeop Kim, Christopher J. Lengner, Yong Kyu Lee, Jongpil Kim

Research output: Contribution to journalArticlepeer-review

243 Scopus citations

Abstract

H. Kim and colleagues generated 3D midbrain organoids containing a G2019S mutation in LRRK2 and used this system for sporadic Parkinson's disease (PD) modeling in vitro. Their results demonstrate that these 3D midbrain organoids can recapitulate the pathological features of LRRK2-associated sporadic PD. These results demonstrate that the 3D midbrain organoids are invaluable for recapitulating PD phenotypes and understanding the molecular underpinnings of these phenotypes.

Original languageEnglish
Pages (from-to)518-531
Number of pages14
JournalStem Cell Reports
Volume12
Issue number3
DOIs
StatePublished - 5 Mar 2019

Keywords

  • Parkinson's disease
  • disease modeling
  • iPSC
  • midbrain
  • organoids

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