Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids

Hongwon Kim; Hyeok Ju Park; Hwan Choi; Yujung Chang; Hanseul Park; Jaein Shin; Junyeop Kim; Christopher J. Lengner; Yong Kyu Lee; Jongpil Kim

doi:10.1016/j.stemcr.2019.01.020

Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids

Hongwon Kim
, Hyeok Ju Park
, Hwan Choi
, Yujung Chang
, Hanseul Park
, Jaein Shin
, Junyeop Kim
, Christopher J. Lengner
, Yong Kyu Lee
, Jongpil Kim

Department of Chemistry

Dongguk University
University of Pennsylvania

Research output: Contribution to journal › Article › peer-review

303 Scopus citations

Abstract

H. Kim and colleagues generated 3D midbrain organoids containing a G2019S mutation in LRRK2 and used this system for sporadic Parkinson's disease (PD) modeling in vitro. Their results demonstrate that these 3D midbrain organoids can recapitulate the pathological features of LRRK2-associated sporadic PD. These results demonstrate that the 3D midbrain organoids are invaluable for recapitulating PD phenotypes and understanding the molecular underpinnings of these phenotypes.

Original language	English
Pages (from-to)	518-531
Number of pages	14
Journal	Stem Cell Reports
Volume	12
Issue number	3
DOIs	https://doi.org/10.1016/j.stemcr.2019.01.020
State	Published - 5 Mar 2019

Keywords

Parkinson's disease
disease modeling
iPSC
midbrain
organoids

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10.1016/j.stemcr.2019.01.020

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title = "Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids",

abstract = "H. Kim and colleagues generated 3D midbrain organoids containing a G2019S mutation in LRRK2 and used this system for sporadic Parkinson's disease (PD) modeling in vitro. Their results demonstrate that these 3D midbrain organoids can recapitulate the pathological features of LRRK2-associated sporadic PD. These results demonstrate that the 3D midbrain organoids are invaluable for recapitulating PD phenotypes and understanding the molecular underpinnings of these phenotypes.",

keywords = "Parkinson's disease, disease modeling, iPSC, midbrain, organoids",

author = "Hongwon Kim and Park, \{Hyeok Ju\} and Hwan Choi and Yujung Chang and Hanseul Park and Jaein Shin and Junyeop Kim and Lengner, \{Christopher J.\} and Lee, \{Yong Kyu\} and Jongpil Kim",

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doi = "10.1016/j.stemcr.2019.01.020",

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T1 - Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids

AU - Kim, Hongwon

AU - Park, Hyeok Ju

AU - Choi, Hwan

AU - Chang, Yujung

AU - Park, Hanseul

AU - Shin, Jaein

AU - Kim, Junyeop

AU - Lengner, Christopher J.

AU - Lee, Yong Kyu

AU - Kim, Jongpil

PY - 2019/3/5

Y1 - 2019/3/5

N2 - H. Kim and colleagues generated 3D midbrain organoids containing a G2019S mutation in LRRK2 and used this system for sporadic Parkinson's disease (PD) modeling in vitro. Their results demonstrate that these 3D midbrain organoids can recapitulate the pathological features of LRRK2-associated sporadic PD. These results demonstrate that the 3D midbrain organoids are invaluable for recapitulating PD phenotypes and understanding the molecular underpinnings of these phenotypes.

AB - H. Kim and colleagues generated 3D midbrain organoids containing a G2019S mutation in LRRK2 and used this system for sporadic Parkinson's disease (PD) modeling in vitro. Their results demonstrate that these 3D midbrain organoids can recapitulate the pathological features of LRRK2-associated sporadic PD. These results demonstrate that the 3D midbrain organoids are invaluable for recapitulating PD phenotypes and understanding the molecular underpinnings of these phenotypes.

KW - Parkinson's disease

KW - disease modeling

KW - iPSC

KW - midbrain

KW - organoids

UR - https://www.scopus.com/pages/publications/85062101346

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DO - 10.1016/j.stemcr.2019.01.020

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AN - SCOPUS:85062101346

SN - 2213-6711

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SP - 518

EP - 531

JO - Stem Cell Reports

JF - Stem Cell Reports

IS - 3

ER -

Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids

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