Monoclonal antibody-conjugated dendritic nanostructures for siRNA delivery

Hitesh Kulhari, Ashok K. Jangid, David J. Adams

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

9 Scopus citations

Abstract

Small interfering RNA (siRNA) is a promising tool for gene therapy-based disease treatments. However, delivery of siRNA to the target cells requires a specific and reliable carrier system. Herein we describe a targeted carrier system that can deliver siRNA to cancer cells overexpressing the human epidermal growth factor 2 (HER2) receptor. Trastuzumab-conjugated poly(amido)amine dendrimers can be synthesized using the protocols described here.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages195-201
Number of pages7
DOIs
StatePublished - 2019

Publication series

NameMethods in Molecular Biology
Volume1974
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Bioconjugation
  • Dendrimers
  • HER2 receptors
  • siRNA delivery
  • Trastuzumab

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