Monoclonal antibody-conjugated dendritic nanostructures for siRNA delivery

Hitesh Kulhari; Ashok K. Jangid; David J. Adams

doi:10.1007/978-1-4939-9220-1_14

Monoclonal antibody-conjugated dendritic nanostructures for siRNA delivery

Hitesh Kulhari
, Ashok K. Jangid
, David J. Adams

Department of Chemical and Biochemical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

9 Scopus citations

Abstract

Small interfering RNA (siRNA) is a promising tool for gene therapy-based disease treatments. However, delivery of siRNA to the target cells requires a specific and reliable carrier system. Herein we describe a targeted carrier system that can deliver siRNA to cancer cells overexpressing the human epidermal growth factor 2 (HER2) receptor. Trastuzumab-conjugated poly(amido)amine dendrimers can be synthesized using the protocols described here.

Original language	English
Title of host publication	Methods in Molecular Biology
Publisher	Humana Press Inc.
Pages	195-201
Number of pages	7
DOIs	https://doi.org/10.1007/978-1-4939-9220-1_14
State	Published - 2019

Publication series

Name	Methods in Molecular Biology
Volume	1974
ISSN (Print)	1064-3745
ISSN (Electronic)	1940-6029

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Bioconjugation
Dendrimers
HER2 receptors
siRNA delivery
Trastuzumab

Access to Document

10.1007/978-1-4939-9220-1_14

Cite this

@inbook{24e6d31c1ad148fbb7067e9908094e21,

title = "Monoclonal antibody-conjugated dendritic nanostructures for siRNA delivery",

abstract = "Small interfering RNA (siRNA) is a promising tool for gene therapy-based disease treatments. However, delivery of siRNA to the target cells requires a specific and reliable carrier system. Herein we describe a targeted carrier system that can deliver siRNA to cancer cells overexpressing the human epidermal growth factor 2 (HER2) receptor. Trastuzumab-conjugated poly(amido)amine dendrimers can be synthesized using the protocols described here.",

keywords = "Bioconjugation, Dendrimers, HER2 receptors, siRNA delivery, Trastuzumab",

author = "Hitesh Kulhari and Jangid, \{Ashok K.\} and Adams, \{David J.\}",

note = "Publisher Copyright: {\textcopyright} Springer Science+Business Media, LLC, part of Springer Nature 2019.",

year = "2019",

doi = "10.1007/978-1-4939-9220-1\_14",

language = "English",

series = "Methods in Molecular Biology",

publisher = "Humana Press Inc.",

pages = "195--201",

booktitle = "Methods in Molecular Biology",

}

TY - CHAP

T1 - Monoclonal antibody-conjugated dendritic nanostructures for siRNA delivery

AU - Kulhari, Hitesh

AU - Jangid, Ashok K.

AU - Adams, David J.

N1 - Publisher Copyright: © Springer Science+Business Media, LLC, part of Springer Nature 2019.

PY - 2019

Y1 - 2019

N2 - Small interfering RNA (siRNA) is a promising tool for gene therapy-based disease treatments. However, delivery of siRNA to the target cells requires a specific and reliable carrier system. Herein we describe a targeted carrier system that can deliver siRNA to cancer cells overexpressing the human epidermal growth factor 2 (HER2) receptor. Trastuzumab-conjugated poly(amido)amine dendrimers can be synthesized using the protocols described here.

AB - Small interfering RNA (siRNA) is a promising tool for gene therapy-based disease treatments. However, delivery of siRNA to the target cells requires a specific and reliable carrier system. Herein we describe a targeted carrier system that can deliver siRNA to cancer cells overexpressing the human epidermal growth factor 2 (HER2) receptor. Trastuzumab-conjugated poly(amido)amine dendrimers can be synthesized using the protocols described here.

KW - Bioconjugation

KW - Dendrimers

KW - HER2 receptors

KW - siRNA delivery

KW - Trastuzumab

UR - https://www.scopus.com/pages/publications/85066139573

U2 - 10.1007/978-1-4939-9220-1_14

DO - 10.1007/978-1-4939-9220-1_14

M3 - Chapter

C2 - 31099004

AN - SCOPUS:85066139573

T3 - Methods in Molecular Biology

SP - 195

EP - 201

BT - Methods in Molecular Biology

PB - Humana Press Inc.

ER -

Monoclonal antibody-conjugated dendritic nanostructures for siRNA delivery

Abstract

Publication series

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this