TY - JOUR
T1 - Morin protects acute liver damage by carbon tetrachloride (CCl4) in rat
AU - Lee, Hee Seung
AU - Jung, Kyung Hee
AU - Hong, Sang Won
AU - Park, In Suh
AU - Lee, Chongmu
AU - Han, Hyo Kyung
AU - Lee, Don Haeng
AU - Hong, Soon Sun
PY - 2008/9
Y1 - 2008/9
N2 - The purpose of this study was to investigate possible beneficial effects of morin on CCl4-induced acute hepatotoxicity in rats. Rats received a single dose of CCl4 (150 μL/100 g 1:1 in corn oil). Morin treatment (20 mg/kg) was given at 48, 24, and 2 h before CCl4 administration. CCl4 challenge elevated serum alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP) levels, but these effects were prevented by the pretreatment of rats with morin. To identify the mechanism of protective activity of morin in CCl4-induced hepatotoxicity in rats, we investigated expressions of tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), and inducible nitric oxide (iNOS). The expressions of TNF-α, IL-1β, IL-6, and iNOS were increased by CCl4 treatment and increased expressions of those were decreased by morin. These findings suggest that morin prevents acute liver damage by inhibiting the production of TNF-α, IL-1β, IL-6, and iNOS.
AB - The purpose of this study was to investigate possible beneficial effects of morin on CCl4-induced acute hepatotoxicity in rats. Rats received a single dose of CCl4 (150 μL/100 g 1:1 in corn oil). Morin treatment (20 mg/kg) was given at 48, 24, and 2 h before CCl4 administration. CCl4 challenge elevated serum alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP) levels, but these effects were prevented by the pretreatment of rats with morin. To identify the mechanism of protective activity of morin in CCl4-induced hepatotoxicity in rats, we investigated expressions of tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), and inducible nitric oxide (iNOS). The expressions of TNF-α, IL-1β, IL-6, and iNOS were increased by CCl4 treatment and increased expressions of those were decreased by morin. These findings suggest that morin prevents acute liver damage by inhibiting the production of TNF-α, IL-1β, IL-6, and iNOS.
KW - Antioxidant
KW - Carbon tetrachloride (CCl)
KW - Hepatic toxicity
KW - Morin
UR - http://www.scopus.com/inward/record.url?scp=52649146351&partnerID=8YFLogxK
U2 - 10.1007/s12272-001-1283-5
DO - 10.1007/s12272-001-1283-5
M3 - Article
C2 - 18806959
AN - SCOPUS:52649146351
SN - 0253-6269
VL - 31
SP - 1160
EP - 1165
JO - Archives of Pharmacal Research
JF - Archives of Pharmacal Research
IS - 9
ER -