TY - JOUR
T1 - Morning Chronotype Decreases the Risk of Chemotherapy-Induced Peripheral Neuropathy in Women With Breast Cancer
AU - Son, Kyung Lak
AU - Jung, Dooyoung
AU - Lee, Kwang Min
AU - Yeom, Chan Woo
AU - Oh, Gyu Han
AU - Kim, Tae Yong
AU - Im, Seock Ah
AU - Lee, Kyung Hun
AU - Spiegel, David
AU - Hahm, Bong Jin
N1 - Publisher Copyright:
© 2022 The Korean Academy of Medical Sciences. All Rights Reserved.
PY - 2022
Y1 - 2022
N2 - Background: The purpose of this longitudinal prospective cohort study was to investigate the role of chronotype in the incidence of chemotherapy-induced peripheral neuropathy (CIPN) among women with breast cancer. Methods: We recruited women with breast cancer awaiting adjuvant chemotherapy, including four cycles of docetaxel. Participants reported peripheral neuropathy symptoms of numbness/ tingling at the baseline, and at 4weeks after completion of chemotherapy. Candidate psychiatric factors associated with CIPN were assessed at the baseline, using the Composite Scale of Morningness, the Pittsburgh Sleep Quality Index, and the Hospital Anxiety and Depression Scale. To examine the association between chronotype and CIPN, we built logistic regression models, adjusting for demographic, clinical, and other psychiatric variables. Results: Among 48 participants, 29 participants developed CIPN. The morning chronotype was inversely associated with CIPN (odds ratio, 0.06; confidence interval, 0.01-0.74; P= 0.028) after adjusting for age, BMI, education, type of operation, alcohol use, smoking, sleep quality, depression, and anxiety. Conclusion: Our results suggest that the morning chronotype is a protective factor against the development of CIPN in patients with breast cancer who were treated with docetaxel. Trial Registration: ClinicalTrials.gov
AB - Background: The purpose of this longitudinal prospective cohort study was to investigate the role of chronotype in the incidence of chemotherapy-induced peripheral neuropathy (CIPN) among women with breast cancer. Methods: We recruited women with breast cancer awaiting adjuvant chemotherapy, including four cycles of docetaxel. Participants reported peripheral neuropathy symptoms of numbness/ tingling at the baseline, and at 4weeks after completion of chemotherapy. Candidate psychiatric factors associated with CIPN were assessed at the baseline, using the Composite Scale of Morningness, the Pittsburgh Sleep Quality Index, and the Hospital Anxiety and Depression Scale. To examine the association between chronotype and CIPN, we built logistic regression models, adjusting for demographic, clinical, and other psychiatric variables. Results: Among 48 participants, 29 participants developed CIPN. The morning chronotype was inversely associated with CIPN (odds ratio, 0.06; confidence interval, 0.01-0.74; P= 0.028) after adjusting for age, BMI, education, type of operation, alcohol use, smoking, sleep quality, depression, and anxiety. Conclusion: Our results suggest that the morning chronotype is a protective factor against the development of CIPN in patients with breast cancer who were treated with docetaxel. Trial Registration: ClinicalTrials.gov
KW - Adjuvant Chemotherapy
KW - Breast Cancer
KW - Chemotherapy-Induced Peripheral Neuropathy
KW - Chronotype
UR - http://www.scopus.com/inward/record.url?scp=85124329856&partnerID=8YFLogxK
U2 - 10.3346/JKMS.2022.37.E34
DO - 10.3346/JKMS.2022.37.E34
M3 - Article
C2 - 35132840
AN - SCOPUS:85124329856
SN - 1011-8934
VL - 37
JO - Journal of Korean Medical Science
JF - Journal of Korean Medical Science
IS - 5
M1 - e34
ER -