Multifaceted factors causing conflicting outcomes in herb-drug interactions

Young Hee Choi, Young Won Chin

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

Metabolic enzyme and/or transporter-mediated pharmacokinetic (PK) changes in a drug caused by concomitant herbal products have been a primary issue of herb and drug interactions (HDIs), because PK changes of a drug may result in the alternation of efficacy and toxicity. Studies on HDIs have been carried out by predictive in vitro and in vivo preclinical studies, and clinical trials. Nevertheless, the discrepancies between predictive data and the clinical significance on HDIs still exist, and different reports of HDIs add to rather than clarify the confusion regarding the use of herbal products and drug combinations. Here, we briefly review the underlying mechanisms causing PK-based HDIs, and more importantly summarize challenging issues, such as dose and treatment period effects, to be considered in study designs and interpretations of HDI evaluations.

Original languageEnglish
Article number43
Pages (from-to)1-13
Number of pages13
JournalPharmaceutics
Volume13
Issue number1
DOIs
StatePublished - Jan 2021

Keywords

  • Dose
  • Herb-drug interaction
  • Pharmacokinetics
  • Treatment period

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