TY - JOUR
T1 - Multimodal imaging of sustained drug release from 3-D poly(propylene fumarate) (PPF) scaffolds
AU - Choi, Jonghoon
AU - Kim, Kyobum
AU - Kim, Taeho
AU - Liu, Guanshu
AU - Bar-Shir, Amnon
AU - Hyeon, Taeghwan
AU - McMahon, Michael T.
AU - Bulte, Jeff W.M.
AU - Fisher, John P.
AU - Gilad, Assaf A.
PY - 2011/12/10
Y1 - 2011/12/10
N2 - The potential of poly(propylene fumarate) (PPF) scaffolds as drug carriers was investigated and the kinetics of the drug release quantified using magnetic resonance imaging (MRI) and optical imaging. Three different MR contrast agents were used for coating PPF scaffolds. Initially, iron oxide (IONP) or manganese oxide nanoparticles (MONP) carrying the anti-cancer drug doxorubicin were absorbed or mixed with the scaffold and their release into solution at physiological conditions was measured with MRI and optical imaging. A slow (hours to days) and functional release of the drug molecules into the surrounding solution was observed. In order to examine the release properties of proteins and polypeptides, protamine sulfate, a chemical exchange saturation transfer (CEST) MR contrast agent, was attached to the scaffold. Protamine sulfate showed a steady release rate for the first 24 h. Due to its biocompatibility, versatile drug-loading capability and constant release rate, the porous PPF scaffold has potential in various biomedical applications, including MR-guided implantation of drug-dispensing materials, development of drug carrying vehicles, and drug delivery for tumor treatment.
AB - The potential of poly(propylene fumarate) (PPF) scaffolds as drug carriers was investigated and the kinetics of the drug release quantified using magnetic resonance imaging (MRI) and optical imaging. Three different MR contrast agents were used for coating PPF scaffolds. Initially, iron oxide (IONP) or manganese oxide nanoparticles (MONP) carrying the anti-cancer drug doxorubicin were absorbed or mixed with the scaffold and their release into solution at physiological conditions was measured with MRI and optical imaging. A slow (hours to days) and functional release of the drug molecules into the surrounding solution was observed. In order to examine the release properties of proteins and polypeptides, protamine sulfate, a chemical exchange saturation transfer (CEST) MR contrast agent, was attached to the scaffold. Protamine sulfate showed a steady release rate for the first 24 h. Due to its biocompatibility, versatile drug-loading capability and constant release rate, the porous PPF scaffold has potential in various biomedical applications, including MR-guided implantation of drug-dispensing materials, development of drug carrying vehicles, and drug delivery for tumor treatment.
KW - Chemical exchange saturation transfer (CEST)
KW - Doxorubicin
KW - Magnetic resonance imaging (MRI)
KW - Nanoparticles
KW - Poly(propylene fumarate) (PPF)
KW - Protamine sulfate (PS) drug release
UR - http://www.scopus.com/inward/record.url?scp=81255127569&partnerID=8YFLogxK
U2 - 10.1016/j.jconrel.2011.06.035
DO - 10.1016/j.jconrel.2011.06.035
M3 - Article
C2 - 21763735
AN - SCOPUS:81255127569
SN - 0168-3659
VL - 156
SP - 239
EP - 245
JO - Journal of Controlled Release
JF - Journal of Controlled Release
IS - 2
ER -