Nano-graphene oxide composite for in vivo imaging

Sung Chan Jang, Sung Min Kang, Jun Young Lee, Seo Yeong Oh, A. T.Ezhil Vilian, Ilsong Lee, Young Kyu Han, Jeong Hoon Park, Wan Seob Cho, Changhyun Roh, Yun Suk Huh

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Introduction: Positron emission tomography (PET) tracers has the potential to revolutionize cancer imaging and diagnosis. PET tracers offer non-invasive quantitative imaging in biotechnology and biomedical applications, but it requires radioisotopes as radioactive imaging tracers or radiopharmaceuticals. Method: This paper reports the synthesis of18F-nGO-PEG by covalently functionalizing PEG with nano-graphene oxide, and its excellent stability in physiological solutions. Using a green synthesis route, nGO is then functionalized with a biocompatible PEG polymer to acquire high stability in PBS and DMEM. Results and discussion: The radiochemical safety of18F-nGO-PEG was measured by a reactive oxygen species and cell viability test. The biodistribution of18F-nGO-PEG could be observed easily by PET, which suggested the significantly high sensitivity tumor uptake of18F-nGO-PEG and in a tumor bearing CT-26 mouse compared to the control.18F-nGO-PEG was applied successfully as an efficient radiotracer or drug agent in vivo using PET imaging. This article is expected to assist many researchers in the fabrication of18F-labeled graphene-based bio-conjugates with high reproducibility for applications in the biomedicine field.

Original languageEnglish
Pages (from-to)221-234
Number of pages14
JournalInternational Journal of Nanomedicine
Volume13
DOIs
StatePublished - 2018

Keywords

  • Graphene oxide
  • Imaging
  • Nanocomposite
  • Radiotracer

Fingerprint

Dive into the research topics of 'Nano-graphene oxide composite for in vivo imaging'. Together they form a unique fingerprint.

Cite this