Neuroprotective benzyl benzoate glycosides from disporum viridescens roots in HT22 hippocampal neuronal cells

Namki Cho, Heejung Yang, Mina Lee, Jungmoo Huh, Hyeon Woo Kim, Hong Pyo Kim, Sang Hyun Sung

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Bioassay-guided fractionation of the EtOAc extract from Disporum viridescens roots led to the isolation of five new benzyl benzoate glycosides, BBGs (1-5). The neuroprotective activities of the BBGs were screened using neuronal HT22 hippocampal cells. BBG-D (4) significantly protected murine hippocampal HT22 cells against glutamate-induced neurotoxicity by maintaining the antioxidative defense systems such as superoxide dismutase, glutathione reductase, glutathione peroxidase, and the glutathione content. BBG-D, in a dose-and time-dependent manner, increased HO-1 expression through the selective activation of pERK signaling among the MAPK pathways. These results suggest that BBG-D could be a promising candidate for the treatment of neurodegenerative diseases related to glutamate-induced oxidative neuronal cytotoxicity.

Original languageEnglish
Pages (from-to)2291-2297
Number of pages7
JournalJournal of Natural Products
Volume76
Issue number12
DOIs
StatePublished - 27 Dec 2013

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