Neuroprotective Effect of Low Frequency-Pulsed Electromagnetic Fields in Ischemic Stroke

Enerelt Urnukhsaikhan; Tsogbadrakh Mishig-Ochir; Soo Chan Kim; Jung Keug Park; Young Kwon Seo

doi:10.1007/s12010-016-2289-z

Neuroprotective Effect of Low Frequency-Pulsed Electromagnetic Fields in Ischemic Stroke

Enerelt Urnukhsaikhan
, Tsogbadrakh Mishig-Ochir
, Soo Chan Kim
, Jung Keug Park
, Young Kwon Seo

Department of Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Low frequency-pulsed electromagnetic fields (LF-PEMFs) affect many biological processes; however, the fundamental mechanisms responsible for these effects remain unclear. Our study aimed to investigate the effect of LF-PEMFs on neuroprotection after ischemic stroke. C57B6 mice were exposed to LF-PEMF (F = 60 Hz, Bm = 10 mT) after photothrombotic occlusion. We measured the BDNF/TrkB/Akt signaling pathway, pro-apoptotic and pro-survival protein and gene expressions, and the expression of inflammatory mediators and performed behavioral tests in both LF-PEMF-treated and untreated ischemic stroke mice. Our results showed that LF-PEMF treatment promotes activation of the BDNF/TrkB/Akt signaling pathway. Subsequently, pro-survival proteins were significantly increased, while pro-apoptotic proteins and inflammatory mediators were decreased in ischemic stroke mice after LF-PEMF treatment. The results demonstrated that LF-PEMF exposure has a neuroprotective effect after ischemic stroke in mice during the recovery process.

Original language	English
Pages (from-to)	1360-1371
Number of pages	12
Journal	Applied Biochemistry and Biotechnology
Volume	181
Issue number	4
DOIs	https://doi.org/10.1007/s12010-016-2289-z
State	Published - 1 Apr 2017

Keywords

Apoptosis
BDNF
Inflammation
Ischemic stroke
LF-PEMF

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title = "Neuroprotective Effect of Low Frequency-Pulsed Electromagnetic Fields in Ischemic Stroke",

abstract = "Low frequency-pulsed electromagnetic fields (LF-PEMFs) affect many biological processes; however, the fundamental mechanisms responsible for these effects remain unclear. Our study aimed to investigate the effect of LF-PEMFs on neuroprotection after ischemic stroke. C57B6 mice were exposed to LF-PEMF (F = 60 Hz, Bm = 10 mT) after photothrombotic occlusion. We measured the BDNF/TrkB/Akt signaling pathway, pro-apoptotic and pro-survival protein and gene expressions, and the expression of inflammatory mediators and performed behavioral tests in both LF-PEMF-treated and untreated ischemic stroke mice. Our results showed that LF-PEMF treatment promotes activation of the BDNF/TrkB/Akt signaling pathway. Subsequently, pro-survival proteins were significantly increased, while pro-apoptotic proteins and inflammatory mediators were decreased in ischemic stroke mice after LF-PEMF treatment. The results demonstrated that LF-PEMF exposure has a neuroprotective effect after ischemic stroke in mice during the recovery process.",

keywords = "Apoptosis, BDNF, Inflammation, Ischemic stroke, LF-PEMF",

author = "Enerelt Urnukhsaikhan and Tsogbadrakh Mishig-Ochir and Kim, \{Soo Chan\} and Park, \{Jung Keug\} and Seo, \{Young Kwon\}",

note = "Publisher Copyright: {\textcopyright} 2016, Springer Science+Business Media New York.",

year = "2017",

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doi = "10.1007/s12010-016-2289-z",

language = "English",

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T1 - Neuroprotective Effect of Low Frequency-Pulsed Electromagnetic Fields in Ischemic Stroke

AU - Urnukhsaikhan, Enerelt

AU - Mishig-Ochir, Tsogbadrakh

AU - Kim, Soo Chan

AU - Park, Jung Keug

AU - Seo, Young Kwon

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Low frequency-pulsed electromagnetic fields (LF-PEMFs) affect many biological processes; however, the fundamental mechanisms responsible for these effects remain unclear. Our study aimed to investigate the effect of LF-PEMFs on neuroprotection after ischemic stroke. C57B6 mice were exposed to LF-PEMF (F = 60 Hz, Bm = 10 mT) after photothrombotic occlusion. We measured the BDNF/TrkB/Akt signaling pathway, pro-apoptotic and pro-survival protein and gene expressions, and the expression of inflammatory mediators and performed behavioral tests in both LF-PEMF-treated and untreated ischemic stroke mice. Our results showed that LF-PEMF treatment promotes activation of the BDNF/TrkB/Akt signaling pathway. Subsequently, pro-survival proteins were significantly increased, while pro-apoptotic proteins and inflammatory mediators were decreased in ischemic stroke mice after LF-PEMF treatment. The results demonstrated that LF-PEMF exposure has a neuroprotective effect after ischemic stroke in mice during the recovery process.

AB - Low frequency-pulsed electromagnetic fields (LF-PEMFs) affect many biological processes; however, the fundamental mechanisms responsible for these effects remain unclear. Our study aimed to investigate the effect of LF-PEMFs on neuroprotection after ischemic stroke. C57B6 mice were exposed to LF-PEMF (F = 60 Hz, Bm = 10 mT) after photothrombotic occlusion. We measured the BDNF/TrkB/Akt signaling pathway, pro-apoptotic and pro-survival protein and gene expressions, and the expression of inflammatory mediators and performed behavioral tests in both LF-PEMF-treated and untreated ischemic stroke mice. Our results showed that LF-PEMF treatment promotes activation of the BDNF/TrkB/Akt signaling pathway. Subsequently, pro-survival proteins were significantly increased, while pro-apoptotic proteins and inflammatory mediators were decreased in ischemic stroke mice after LF-PEMF treatment. The results demonstrated that LF-PEMF exposure has a neuroprotective effect after ischemic stroke in mice during the recovery process.

KW - Apoptosis

KW - BDNF

KW - Inflammation

KW - Ischemic stroke

KW - LF-PEMF

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JO - Applied Biochemistry and Biotechnology

JF - Applied Biochemistry and Biotechnology

IS - 4

ER -

Neuroprotective Effect of Low Frequency-Pulsed Electromagnetic Fields in Ischemic Stroke

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Keywords

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