TY - JOUR
T1 - New classes of fluorinated L-nucleosides; synthesis and antiviral activity
AU - Lee, Kyeong
AU - Choi, Yongseok
AU - Hong, Joon H.
AU - Schinazi, Raymond F.
AU - Chu, Chung K.
PY - 1999
Y1 - 1999
N2 - The synthesis of 3'-fluorinated apionucleosides 7 and 2'-fluoro-2',3'- unsaturated L-nucleosides 8 via common synthon, 2-fluoro-butenolide 2, has been described. Among the newly synthesized nucleosides, L-2'-F-d4C, L-2'-F- d4FC and L-2'-F-d4A exhibit significant anti-HIV and anti-HBV activities.
AB - The synthesis of 3'-fluorinated apionucleosides 7 and 2'-fluoro-2',3'- unsaturated L-nucleosides 8 via common synthon, 2-fluoro-butenolide 2, has been described. Among the newly synthesized nucleosides, L-2'-F-d4C, L-2'-F- d4FC and L-2'-F-d4A exhibit significant anti-HIV and anti-HBV activities.
UR - http://www.scopus.com/inward/record.url?scp=0032990618&partnerID=8YFLogxK
U2 - 10.1080/15257779908041489
DO - 10.1080/15257779908041489
M3 - Article
C2 - 10432644
AN - SCOPUS:0032990618
SN - 0732-8311
VL - 18
SP - 537
EP - 540
JO - Nucleosides and Nucleotides
JF - Nucleosides and Nucleotides
IS - 4-5
ER -
