New classes of fluorinated L-nucleosides; synthesis and antiviral activity

Kyeong Lee; Yongseok Choi; Joon H. Hong; Raymond F. Schinazi; Chung K. Chu

doi:10.1080/15257779908041489

New classes of fluorinated L-nucleosides; synthesis and antiviral activity

Kyeong Lee
, Yongseok Choi
, Joon H. Hong
, Raymond F. Schinazi
, Chung K. Chu

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

The synthesis of 3'-fluorinated apionucleosides 7 and 2'-fluoro-2',3'- unsaturated L-nucleosides 8 via common synthon, 2-fluoro-butenolide 2, has been described. Among the newly synthesized nucleosides, L-2'-F-d4C, L-2'-F- d4FC and L-2'-F-d4A exhibit significant anti-HIV and anti-HBV activities.

Original language	English
Pages (from-to)	537-540
Number of pages	4
Journal	Nucleosides and Nucleotides
Volume	18
Issue number	4-5
DOIs	https://doi.org/10.1080/15257779908041489
State	Published - 1999

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SDG 3 Good Health and Well-being

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10.1080/15257779908041489

Cite this

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title = "New classes of fluorinated L-nucleosides; synthesis and antiviral activity",

abstract = "The synthesis of 3'-fluorinated apionucleosides 7 and 2'-fluoro-2',3'- unsaturated L-nucleosides 8 via common synthon, 2-fluoro-butenolide 2, has been described. Among the newly synthesized nucleosides, L-2'-F-d4C, L-2'-F- d4FC and L-2'-F-d4A exhibit significant anti-HIV and anti-HBV activities.",

author = "Kyeong Lee and Yongseok Choi and Hong, \{Joon H.\} and Schinazi, \{Raymond F.\} and Chu, \{Chung K.\}",

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pages = "537--540",

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T1 - New classes of fluorinated L-nucleosides; synthesis and antiviral activity

AU - Lee, Kyeong

AU - Choi, Yongseok

AU - Hong, Joon H.

AU - Schinazi, Raymond F.

AU - Chu, Chung K.

PY - 1999

Y1 - 1999

N2 - The synthesis of 3'-fluorinated apionucleosides 7 and 2'-fluoro-2',3'- unsaturated L-nucleosides 8 via common synthon, 2-fluoro-butenolide 2, has been described. Among the newly synthesized nucleosides, L-2'-F-d4C, L-2'-F- d4FC and L-2'-F-d4A exhibit significant anti-HIV and anti-HBV activities.

AB - The synthesis of 3'-fluorinated apionucleosides 7 and 2'-fluoro-2',3'- unsaturated L-nucleosides 8 via common synthon, 2-fluoro-butenolide 2, has been described. Among the newly synthesized nucleosides, L-2'-F-d4C, L-2'-F- d4FC and L-2'-F-d4A exhibit significant anti-HIV and anti-HBV activities.

UR - https://www.scopus.com/pages/publications/0032990618

U2 - 10.1080/15257779908041489

DO - 10.1080/15257779908041489

M3 - Article

C2 - 10432644

AN - SCOPUS:0032990618

SN - 0732-8311

VL - 18

SP - 537

EP - 540

JO - Nucleosides and Nucleotides

JF - Nucleosides and Nucleotides

IS - 4-5

ER -

New classes of fluorinated L-nucleosides; synthesis and antiviral activity

Abstract

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