No association of the MCP-1 promoter A-2518G polymorphism with bipolar disorder in the Korean population

Myoung Sun Roh, Kyu Young Lee, Eun Jeong Joo, Namyoung Lee, Yong Sik Kim

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13 Scopus citations

Abstract

It has been suggested that bipolar disorder is associated with altered immune function. Monocyte chemoattractant protien-1 (MCP-1) is a chemokine that influences both neural and immune functions. We thus hypothesized that MCP-1 may be related to the development or pathophysiology of bipolar disorder. In this case-control study, we investigated the association between the A-2518G single nucleotide polymorphism (SNP) of the MCP-1 promoter and bipolar disorder. Patients with bipolar disorder (n = 183; bipolar I = 145, bipolar II = 38) and healthy controls (350) were recruited for the study. No significant allelic or genotypic association was detected between the A-2518G polymorphism and any sample of bipolar disorder patients. When we pooled the healthy controls and the cases of bipolar I disorder from previous Korean studies and this study, we again found no significant association. No significant difference in either allele frequency or genotype distribution was observed between bipolar I and bipolar II disorders. There was no difference in the age at onset of bipolar disorder among the three genotype groups. Our data suggest that the A-2518G polymorphism of MCP-1 is not a major susceptibility factor for bipolar disorder in the Korean population. However, the physiological role of MCP-1 is highly suggestive of its being associated with bipolar disorder, and further analyses of other SNPs of MCP-1 remain to be performed.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalNeuroscience Letters
Volume427
Issue number1
DOIs
StatePublished - 29 Oct 2007

Keywords

  • Bipolar disorder
  • Monocyte chemoattractant protein-1
  • Polymorphism

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