Nonviral gene transfer strategies to promote bone regeneration

Research output: Contribution to journalReview articlepeer-review

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Abstract

Despite the inherent ability of bone to regenerate itself, there are a number of clinical situations in which complete bone regeneration fails to occur. In view of shortcomings of conventional treatment, gene therapy may have a place in cases of critical-size bone loss that cannot be properly treated with current medical or surgical treatment. The purpose of this review is to provide an overview of gene therapy in general, nonviral techniques of gene transfer including physical and chemical methods, RNA-based therapy, therapeutic genes to be transferred for bone regeneration, route of application including ex vivo application, and direct gene therapy approaches to regenerate bone. ©2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A:3009-3018, 2013.

Original languageEnglish
Pages (from-to)3009-3018
Number of pages10
JournalJournal of Biomedical Materials Research - Part A
Volume101
Issue number10
DOIs
StatePublished - Oct 2013

Keywords

  • bone regeneration
  • gene transfer
  • nonviral

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