Abstract
This paper discusses characteristics of dye biases in microarray data that the conventional normalization methods do not handle, and proposes a new normalization method involving a mixture of splines model. We also develop a test for between-group comparisons of each gene that is designed to be used with our proposed method.
Original language | English |
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Article number | 2 |
Journal | Statistical Applications in Genetics and Molecular Biology |
Volume | 6 |
Issue number | 1 |
DOIs | |
State | Published - 25 Jan 2007 |
Keywords
- Dye bias
- Microarray data
- Mixture of splines