Normalization of dye bias in microarray data using the mixture of splines model

Yongsung Joo, George Casella, James Booth, Keunbaik Lee, Steven Enkemann

Research output: Contribution to journalArticlepeer-review

Abstract

This paper discusses characteristics of dye biases in microarray data that the conventional normalization methods do not handle, and proposes a new normalization method involving a mixture of splines model. We also develop a test for between-group comparisons of each gene that is designed to be used with our proposed method.

Original languageEnglish
Article number2
JournalStatistical Applications in Genetics and Molecular Biology
Volume6
Issue number1
DOIs
StatePublished - 25 Jan 2007

Keywords

  • Dye bias
  • Microarray data
  • Mixture of splines

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