Normalization of dye bias in microarray data using the mixture of splines model

Yongsung Joo; George Casella; James Booth; Keunbaik Lee; Steven Enkemann

doi:10.2202/1544-6115.1228

Normalization of dye bias in microarray data using the mixture of splines model

Yongsung Joo
, George Casella
, James Booth
, Keunbaik Lee
, Steven Enkemann

Department of Statistics

Research output: Contribution to journal › Article › peer-review

Abstract

This paper discusses characteristics of dye biases in microarray data that the conventional normalization methods do not handle, and proposes a new normalization method involving a mixture of splines model. We also develop a test for between-group comparisons of each gene that is designed to be used with our proposed method.

Original language	English
Article number	2
Journal	Statistical Applications in Genetics and Molecular Biology
Volume	6
Issue number	1
DOIs	https://doi.org/10.2202/1544-6115.1228
State	Published - 25 Jan 2007

Keywords

Dye bias
Microarray data
Mixture of splines

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10.2202/1544-6115.1228

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title = "Normalization of dye bias in microarray data using the mixture of splines model",

abstract = "This paper discusses characteristics of dye biases in microarray data that the conventional normalization methods do not handle, and proposes a new normalization method involving a mixture of splines model. We also develop a test for between-group comparisons of each gene that is designed to be used with our proposed method.",

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AU - Joo, Yongsung

AU - Casella, George

AU - Booth, James

AU - Lee, Keunbaik

AU - Enkemann, Steven

PY - 2007/1/25

Y1 - 2007/1/25

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AB - This paper discusses characteristics of dye biases in microarray data that the conventional normalization methods do not handle, and proposes a new normalization method involving a mixture of splines model. We also develop a test for between-group comparisons of each gene that is designed to be used with our proposed method.

KW - Dye bias

KW - Microarray data

KW - Mixture of splines

UR - https://www.scopus.com/pages/publications/33846528849

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DO - 10.2202/1544-6115.1228

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SN - 1544-6115

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Normalization of dye bias in microarray data using the mixture of splines model

Abstract

Keywords

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