Occupational lead exposure and brain tumors: Systematic review and meta-analysis

Joonho Ahn, Mi Yeon Park, Mo Yeol Kang, In Soo Shin, Sungjae An, Hyoung Ryoul Kim

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

(1) Background: Due to inconsistencies in epidemiological findings, there has been uncertainty regarding the association of lead compounds with brain tumors. We performed a meta-analysis of published case-control and cohort studies exploring lead compound exposure and brain tumor risk. (2) Methods: We searched PubMed, Embase®, and Cochrane to find eligible studies. Eighteen studies were selected for assessment of occupational exposure to lead compound and brain tumor. Pooled estimates of odds ratios (ORs) were obtained using random effects models. We assessed the differences through subgroup analysis according to tumor type, study design, measurements of exposure, and tumor outcome. Statistical tests for publication bias, heterogeneity, and sensitivity analysis were applied. (3) Results: Our systematic review and meta-analysis showed a not significant association with lead exposure and risk of benign and malignant brain tumors (pooled OR = 1.11, 95% Confidence Interval (CI): 0.95–1.29). Including only malignant brain tumors, the risk of brain tumor was significantly increased (pooled OR = 1.13, 95% CI: 1.04–1.24). (4) Conclusions: This meta-analysis provides suggestive evidence for an association between lead compound exposure and brain tumor. In future studies, it will be necessary to identify the effect of lead compounds according to the types of brain tumor.

Original languageEnglish
Article number3975
Pages (from-to)1-14
Number of pages14
JournalInternational Journal of Environmental Research and Public Health
Volume17
Issue number11
DOIs
StatePublished - 1 Jun 2020

Keywords

  • Brain tumor
  • Carcinogen
  • Lead compound
  • Meta-analysis

Fingerprint

Dive into the research topics of 'Occupational lead exposure and brain tumors: Systematic review and meta-analysis'. Together they form a unique fingerprint.

Cite this