One-pot synthesis of multifunctional Au@Graphene oxide nanocolloid core@shell nanoparticles for raman bioimaging, photothermal, and photodynamic therapy

Young Kwan Kim, Hee Kyung Na, Seongchan Kim, Hongje Jang, Sung Jin Chang, Dal Hee Min

Research output: Contribution to journalArticlepeer-review

122 Scopus citations

Abstract

The paper reports a facile one-pot synthesis of core@shell nanoparticles (NPs) composed of Au core and graphene oxide nanocolloid (GON) shell. Unique properties of Au NPs and GON can be incorporated into a single nanohybrid structure to provide desirable functions for theranosis such as localized surface plasmon resonance, Raman scattering, amphiphilic surface, and photothermal conversion. Synthesis of Au@GON NPs is achieved by simple one-pot reaction in aqueous phase utilizing GON as a reducing and stabilizing agent without any additional reducing agent. The zinc phthalocyanine, a photosensitizer, loaded Au@GON NPs show excellent multifunctional properties for combinational treatment of photothermal and photodynamic therapy in addition to Raman bioimaging with low cytotoxicity.

Original languageEnglish
Pages (from-to)2527-2535
Number of pages9
JournalSmall
Volume11
Issue number21
DOIs
StatePublished - 1 Jun 2015

Keywords

  • Raman spectroscopy
  • combination therapy
  • graphene oxide
  • nanoparticles
  • surface plasmon resonances

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