TY - JOUR
T1 - Ophthalmic Sensors and Drug Delivery
AU - Dennyson Savariraj, Antonysamy
AU - Salih, Ahmed
AU - Alam, Fahad
AU - Elsherif, Mohamed
AU - Alqattan, Bader
AU - Khan, Ammar A.
AU - Yetisen, Ali K.
AU - Butt, Haider
N1 - Publisher Copyright:
© 2021 American Chemical Society. All rights reserved.
PY - 2021/6/25
Y1 - 2021/6/25
N2 - Advances in multifunctional materials and technologies have allowed contact lenses to serve as wearable devices for continuous monitoring of physiological parameters and delivering drugs for ocular diseases. Since the tear fluids comprise a library of biomarkers, direct measurement of different parameters such as concentration of glucose, urea, proteins, nitrite, and chloride ions, intraocular pressure (IOP), corneal temperature, and pH can be carried out non-invasively using contact lens sensors. Microfluidic contact lens sensor based colorimetric sensing and liquid control mechanisms enable the wearers to perform self-examinations at home using smartphones. Furthermore, drug-laden contact lenses have emerged as delivery platforms using a low dosage of drugs with extended residence time and increased ocular bioavailability. This review provides an overview of contact lenses for ocular diagnostics and drug delivery applications. The designs, working principles, and sensing mechanisms of sensors and drug delivery systems are reviewed. The potential applications of contact lenses in point-of-care diagnostics and personalized medicine, along with the significance of integrating multiplexed sensing units together with drug delivery systems, have also been discussed.
AB - Advances in multifunctional materials and technologies have allowed contact lenses to serve as wearable devices for continuous monitoring of physiological parameters and delivering drugs for ocular diseases. Since the tear fluids comprise a library of biomarkers, direct measurement of different parameters such as concentration of glucose, urea, proteins, nitrite, and chloride ions, intraocular pressure (IOP), corneal temperature, and pH can be carried out non-invasively using contact lens sensors. Microfluidic contact lens sensor based colorimetric sensing and liquid control mechanisms enable the wearers to perform self-examinations at home using smartphones. Furthermore, drug-laden contact lenses have emerged as delivery platforms using a low dosage of drugs with extended residence time and increased ocular bioavailability. This review provides an overview of contact lenses for ocular diagnostics and drug delivery applications. The designs, working principles, and sensing mechanisms of sensors and drug delivery systems are reviewed. The potential applications of contact lenses in point-of-care diagnostics and personalized medicine, along with the significance of integrating multiplexed sensing units together with drug delivery systems, have also been discussed.
KW - bioavailability
KW - biomaterials
KW - biosensors
KW - contact lenses, continuous monitoring
KW - diagnostics
KW - drug delivery
KW - ophthalmology
KW - personalized medicine
KW - photonic crystals
KW - physiological parameters
UR - http://www.scopus.com/inward/record.url?scp=85108446919&partnerID=8YFLogxK
U2 - 10.1021/acssensors.1c00370
DO - 10.1021/acssensors.1c00370
M3 - Review article
C2 - 34043907
AN - SCOPUS:85108446919
SN - 2379-3694
VL - 6
SP - 2046
EP - 2076
JO - ACS Sensors
JF - ACS Sensors
IS - 6
ER -