@inproceedings{f55bf963f93445c6aa84cdd05605580b,
title = "Optical stimulation of cultured neurons in 3D microfluidic device coupled to planar microelectrode-arrays",
abstract = "Here, we describe a novel microfluidic system for the optical stimulation of 3D in-vitro neurons. The system was designed to stimulate optically 3D neurons and to record electrically their activity using electrode-arrays measurement. The microfluidic technique enabled to maintain 3D hydrogel structure on the MEAs. We stimulated 3D neurons using the visible light with the commercial caged glutamate. We explored optimum visible light parameters to evoke action potentials in 3D neurons, compared to in 2D neurons. We expect that this technique should open up a new possibility of neural stimulation study in general as well as be utilized for another optical stimulation.",
keywords = "3D neuron, Matrigel, Micro-electrode arrays, Optical stimulation",
author = "Jang, {Jae Myung} and Sangcheol Na and Seokyoung Bang and Jeon, {Noo Li}",
note = "Publisher Copyright: {\textcopyright} 15CBMS-0001.; 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 ; Conference date: 25-10-2015 Through 29-10-2015",
year = "2015",
language = "English",
series = "MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Chemical and Biological Microsystems Society",
pages = "1283--1286",
booktitle = "MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
}