Orally administered collagen peptide protects against UVB-induced skin aging through the absorption of dipeptide forms, Gly-Pro and Pro-Hyp

Hyun Jun Lee, Hye Lim Jang, Dong Kyu Ahn, Hun Jung Kim, Hee Young Jeon, Dae Bang Seo, Ji Hae Lee, Jin Kyu Choi, Seok Seong Kang

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Collagen hydrolysate is a well-known nutritional supplement for the improvement of healthy skin. Here, collagen peptide NS (CPNS) from fish scale was prepared, and its physicochemical properties were investigated. Gly-Pro was revealed as a representative low molecular weight peptide of CPNS, by performing prep-HPLC and LC-MS/MS. CPNS treatment attenuated matrix metalloproteinase-1 production and increased the synthesis of type 1 procollagen in HDF cells. After orally administering CPNS to rats, the plasma concentrations of Gly-Pro and Pro-Hyp increased dramatically. To examine the protective effects of CPNS against ultraviolet B (UVB)-induced photoaging in vivo, the dorsal skins of hairless mice were exposed to UVB and supplemented with CPNS for 12 weeks. The CPNS consumption significantly attenuated UVB-induced wrinkle formation, transepidermal water loss, and epidermis thickness, and increased skin hydration. Collectively, these results suggest that bioactive peptides of CPNS, Gly-Pro and Pro-Hyp, exert beneficial effects on skin health.

Original languageEnglish
Pages (from-to)1146-1156
Number of pages11
JournalBioscience, Biotechnology and Biochemistry
Volume83
Issue number6
DOIs
StatePublished - 2019

Keywords

  • Bioactive peptide
  • Collagen hydrolysate
  • Gly-Pro
  • Pro-Hyp
  • Skin health

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