Abstract
Mesenchymal stem cells (MSCs) from bone marrow have been investigated as the most suitable cell source for bone tissue engineering for their excellent osteogenic potential under the proper conditions. Recently, adipose stem cells (ASCs) have been added to the armentarium as a cell source due to their abundance and easy accessibility. To develop a strategy to induce osteogenesis from these various stem cells, an understanding of the signaling pathways including key transcription factors regulating osteoblastic differentiation and osteogenic growth factor is essential. In this review, we summarized on these factors and the methods for gene transfer of these factors to enhance osteogenic potentials of adult stem cells as well as brief introduction about bone tissue engineering.
Original language | English |
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Pages (from-to) | 347-352 |
Number of pages | 6 |
Journal | Tissue Engineering and Regenerative Medicine |
Volume | 8 |
Issue number | 4 |
State | Published - Jul 2011 |
Keywords
- Adipose stem cells
- Bone
- Mesenchymal stem cells
- Osteogenic differentiation
- Tissue engineering