Osteogenic differentiation of mesenchymal stem cells and bone tissue engineering

T. S. Shanmugarajan, Gun Il Im

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Mesenchymal stem cells (MSCs) from bone marrow have been investigated as the most suitable cell source for bone tissue engineering for their excellent osteogenic potential under the proper conditions. Recently, adipose stem cells (ASCs) have been added to the armentarium as a cell source due to their abundance and easy accessibility. To develop a strategy to induce osteogenesis from these various stem cells, an understanding of the signaling pathways including key transcription factors regulating osteoblastic differentiation and osteogenic growth factor is essential. In this review, we summarized on these factors and the methods for gene transfer of these factors to enhance osteogenic potentials of adult stem cells as well as brief introduction about bone tissue engineering.

Original languageEnglish
Pages (from-to)347-352
Number of pages6
JournalTissue Engineering and Regenerative Medicine
Volume8
Issue number4
StatePublished - Jul 2011

Keywords

  • Adipose stem cells
  • Bone
  • Mesenchymal stem cells
  • Osteogenic differentiation
  • Tissue engineering

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