Osteolysis in total knee arthroplasty

Gun Il Im, Arun S. Shanbhag, Richard Berger, Harry E. Rubash

Research output: Contribution to journalReview articlepeer-review

Abstract

Osteolysis is the consequence of biological activity in response to particulate debris at the bone-implant interface. Despite the documented problem of knee component wear, osteolysis around total knee arthroplasty (TKA) has only recently been recognized as a clinical problem. There are important differences between wear particles from TKA and total hip arthroplasty (THA) that are attributed to kinematic differences between the two joints. These factors and others determine the variation in biological response and the subsequent incidence of osteolysis in joint replacements. In this review, we compared the pathophysiology of osteolysis in TKA and THA, including wear debris production and the biological response to particulate debris. We also summarized the incidence of osteolysis in TKA based on previously published reports. Finally, the principles of the diagnosis and management of osteolysis after TKA are reviewed.

Original languageEnglish
Pages (from-to)255-274
Number of pages20
JournalSeminars in Arthroplasty JSES
Volume13
Issue number4
StatePublished - Oct 2002

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