P53 signalling mediates acupuncture-induced neuroprotection in Parkinson's disease

Ji Yeun Park, Hwan Choi, Soonbong Baek, Jaehwan Jang, Ahreum Lee, Songhee Jeon, Jongpil Kim, Hi Joon Park

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder associated with a selective loss of dopamine (DA) neurons in the substantia nigra of the midbrain. Recently, it has been demonstrated that acupuncture treatment has protective effects in PD. However, to date, the molecular mechanisms underlying acupuncture's effect on DA neuronal protection are largely unknown. In this study, we report that p53 signalling mediates the protective effects of acupuncture treatment in a mouse model of PD. We found that the acupuncture treatment in the mouse PD model results in significant recovery to the normal in the context of behaviour and molecular signatures. We found that the gene network associated with p53 signalling is closely involved in the protective effects of acupuncture treatment in PD. Consistent with this idea, we demonstrated that specific knockout of the p53 gene in the midbrain DA neurons abrogates the acupuncture induced protective effects in the mouse model of PD. Thus, these data suggest that p53 signalling mediates the protective effects of acupuncture treatment in PD.

Original languageEnglish
Pages (from-to)772-779
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume460
Issue number3
DOIs
StatePublished - 2 May 2015

Keywords

  • Acupuncture
  • Mechanism
  • Parkinson's disease

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