Palladium-Catalyzed Synthesis of Pyrrolo[1,2-α]Pyrazines From N-Phenacyl Pyrrole-2-Carbonitriles and Aryl Boronic Acids

Hyejun Park, Seunghwan Shim, Hayoung Jeon, Hwayoung Lee, Kiho Lee, Kyeong Lee, Jae Kyun Lee, Hitesh B. Jalani, Yongseok Choi

Research output: Contribution to journalArticlepeer-review

Abstract

Herein, we have developed palladium-trifluoroacetate-catalyzed carbo-palladation reaction of pyrrole-2-carbonitriles and aryl boronic acids leading to functionally diverse pyrrolo[1,2-α]pyrazines under thoroughly optimized reaction conditions. The reaction proceeded smoothly and allowed the diversity-oriented synthesis of pyrrolo[1,2-α]pyrazines with broad substrate scope with respect to pyrrole-2-carbonitriles and aryl boronic acids.

Original languageEnglish
Pages (from-to)1899-1907
Number of pages9
JournalJournal of Heterocyclic Chemistry
Volume61
Issue number11
DOIs
StatePublished - Nov 2024

Keywords

  • N-phenacyl pyrrole-2-carbonitriles
  • aryl boronic acids
  • carbo-palladation
  • pd(TFA)
  • pyrrolo[1,2-α]pyrazines

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