Abstract
Herein, we have developed palladium-trifluoroacetate-catalyzed carbo-palladation reaction of pyrrole-2-carbonitriles and aryl boronic acids leading to functionally diverse pyrrolo[1,2-α]pyrazines under thoroughly optimized reaction conditions. The reaction proceeded smoothly and allowed the diversity-oriented synthesis of pyrrolo[1,2-α]pyrazines with broad substrate scope with respect to pyrrole-2-carbonitriles and aryl boronic acids.
Original language | English |
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Pages (from-to) | 1899-1907 |
Number of pages | 9 |
Journal | Journal of Heterocyclic Chemistry |
Volume | 61 |
Issue number | 11 |
DOIs | |
State | Published - Nov 2024 |
Keywords
- N-phenacyl pyrrole-2-carbonitriles
- aryl boronic acids
- carbo-palladation
- pd(TFA)
- pyrrolo[1,2-α]pyrazines