Penfluridol as a candidate of drug repurposing for anticancer agent

Nguyen Minh Tuan, Chang Hoon Lee

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

Penfluridol has robust antipsychotic efficacy and is a first-generation diphenylbutylpiperidine. Its effects last for several days after a single oral dose and it can be administered once a week to provide better compliance and symptom control. Recently; strong antitumour effects for penfluridol were discovered in various cancer cell lines; such as breast; pancreatic; glioblastoma; and lung cancer cells via several distinct mechanisms. Therefore; penfluridol has drawn much attention as a potentially novel anti-tumour agent. In addition; the anti-cancer effects of penfluridol have been demonstrated in vivo: results showed slight changes in the volume and weight of organs at doses tested in animals. This paper outlines the potential for penfluridol to be developed as a next-generation anticancer drug.

Original languageEnglish
Article number3659
JournalMolecules
Volume24
Issue number20
DOIs
StatePublished - 11 Oct 2019

Keywords

  • Antipsychotic
  • Autophagy
  • Drug repositioning
  • Glioblastoma
  • Hallmarks of cancer
  • Penfluridol

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