Periodic charge matching driven immobilization of gentamicin in nanoclays for stable and long-term antibacterial coating

Tetsuo Yamaguchi, Su Joung Ko, Jin Song Jung, Hyoung Jun Kim, Jae Min Oh

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Matching of charge periodicity between a guest and a host enabled effective immobilization of highly water-soluble antibiotic drug, gentamicin C, in a bentonite clay by cation exchange. X-ray diffraction, infrared spectroscopy and CHNS analysis revealed the immobilization manner of gentamicin C, which was immobilized between bentonite layersviaperiodic charge-charge interaction with tilted arrangement, as a trication. Both gentamicin alone and a gentamicin/bentonite hybrid were coated onto a polyurethane substrate using water-borne polyurethane binder. The antibiotic character of both films was investigated as prepared or after immersion in phosphate-buffered saline till 5 days againstE. coliandB. subtilisbacteria. It was clearly shown that the gentamicin/bentonite hybrid-coated film showed sustained antibacterial efficacy even after exposure to phosphate-buffered saline, while gentamicin only-coated film gradually lost its performance under the same condition.

Original languageEnglish
Pages (from-to)14216-14222
Number of pages7
JournalDalton Transactions
Volume50
Issue number40
DOIs
StatePublished - 28 Oct 2021

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