TY - JOUR
T1 - Perspective on Intra-articular Injection Cell Therapy for Osteoarthritis Treatment
AU - Im, Gun Il
N1 - Publisher Copyright:
© 2019, The Korean Tissue Engineering and Regenerative Medicine Society and Springer Nature B.V.
PY - 2019/8/14
Y1 - 2019/8/14
N2 - Background:: Osteoarthritis (OA), the most common arthritis, is one of the most frequently encountered orthopaedic conditions. As a small number of large joints such as knee and hip are affected in OA, OA is an ideal target for local therapy. Although corticosteroid and hyaluronic acid have been traditionally used for joints through intra-articular (IA) injection, IA injection also provides a minimally invasive route to apply cell therapy to treat OA. IA cell therapy has drawn attention because it may provide regeneration of articular cartilage in addition to palliative anti-inflammatory effects. Methods:: Current progress of IA injection therapy and the author’s perspective on this issue are described narratively. Results:: It is too premature to have any conclusion on the eventual efficacy of IA cell therapy concerning regeneration of articular cartilage based on current data. Prospective radiological and histological data from larger numbers of patients are needed to prove cost effectiveness of IA cell therapy. Conclusions:: Expanding research in this field will produce further evidences to provide guidance on the eventual effectiveness of IA cell therapy in the future.
AB - Background:: Osteoarthritis (OA), the most common arthritis, is one of the most frequently encountered orthopaedic conditions. As a small number of large joints such as knee and hip are affected in OA, OA is an ideal target for local therapy. Although corticosteroid and hyaluronic acid have been traditionally used for joints through intra-articular (IA) injection, IA injection also provides a minimally invasive route to apply cell therapy to treat OA. IA cell therapy has drawn attention because it may provide regeneration of articular cartilage in addition to palliative anti-inflammatory effects. Methods:: Current progress of IA injection therapy and the author’s perspective on this issue are described narratively. Results:: It is too premature to have any conclusion on the eventual efficacy of IA cell therapy concerning regeneration of articular cartilage based on current data. Prospective radiological and histological data from larger numbers of patients are needed to prove cost effectiveness of IA cell therapy. Conclusions:: Expanding research in this field will produce further evidences to provide guidance on the eventual effectiveness of IA cell therapy in the future.
KW - Cartilage regeneration
KW - Cell therapy
KW - Intra-articular injection
KW - Osteoarthritis treatment
UR - http://www.scopus.com/inward/record.url?scp=85069898889&partnerID=8YFLogxK
U2 - 10.1007/s13770-018-00176-6
DO - 10.1007/s13770-018-00176-6
M3 - Review article
C2 - 31413940
AN - SCOPUS:85069898889
SN - 1738-2696
VL - 16
SP - 357
EP - 363
JO - Tissue Engineering and Regenerative Medicine
JF - Tissue Engineering and Regenerative Medicine
IS - 4
ER -