TY - JOUR
T1 - PH sensitive poly(methyl methacrylate-co-acryloyl phenylalanine) nanogels and their silver nanocomposites for biomedical applications
AU - Rama Subba Reddy, P.
AU - Krishna Rao, K. S.V.
AU - Madhusudana Rao, K.
AU - Sivagangi Reddy, N.
AU - Eswaramma, S.
N1 - Publisher Copyright:
© 2015 Elsevier B.V. All rights reserved.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Poly (methyl methacrylate-co-acryloylphenylalanine) (PMAPA) nanogels (NGs) were developed by a simple surfactant free emulsion polymerization method. PMAPA NGs were composed from the copolymerization of MMA, APA crosslinked with EGDMA. A green approach was employed to synthesize silver nanoparticles in PMAPA NG networks using leaf extract of Limonia acidissima. The NGs and their silver nanocomposite were used for controlled release of 5-Fluorouracil and antimicrobial activity against Bacilli and Escherichia coli, respectively. Chemical, structural interactions, thermal and morphological properties of PMAPA nano hydrogels are characterized by FTIR, XRD, DSC, TEM and DLS, respectively. The average size of nano hydrogels were achieved up to 40e120 nm. The % encapsulation efficiency was achieved up to 53.43 ± 1.7 by equilibrium swelling method.
AB - Poly (methyl methacrylate-co-acryloylphenylalanine) (PMAPA) nanogels (NGs) were developed by a simple surfactant free emulsion polymerization method. PMAPA NGs were composed from the copolymerization of MMA, APA crosslinked with EGDMA. A green approach was employed to synthesize silver nanoparticles in PMAPA NG networks using leaf extract of Limonia acidissima. The NGs and their silver nanocomposite were used for controlled release of 5-Fluorouracil and antimicrobial activity against Bacilli and Escherichia coli, respectively. Chemical, structural interactions, thermal and morphological properties of PMAPA nano hydrogels are characterized by FTIR, XRD, DSC, TEM and DLS, respectively. The average size of nano hydrogels were achieved up to 40e120 nm. The % encapsulation efficiency was achieved up to 53.43 ± 1.7 by equilibrium swelling method.
KW - Anti-cancer drug
KW - Antimicrobial activity
KW - Controlled drug release
KW - Emulsion free polymerization
KW - Nanogels
KW - Silver nano composite
UR - http://www.scopus.com/inward/record.url?scp=84942235259&partnerID=8YFLogxK
U2 - 10.1016/j.jddst.2015.07.002
DO - 10.1016/j.jddst.2015.07.002
M3 - Article
AN - SCOPUS:84942235259
SN - 1773-2247
VL - 29
SP - 181
EP - 188
JO - Journal of Drug Delivery Science and Technology
JF - Journal of Drug Delivery Science and Technology
ER -
