Pharmacokinetic interaction between fluvastatin and diltiazem in rats

Jun Shik Choi, Yong Ji Piao, Hyo Kyung Han

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The present study aimed to investigate the effect of fluvastatin on the pharmacokinetics of diltiazem in rats. Pharmacokinetic parameters of diltiazem were determined in rats following an oral administration of diltiazem (15 mg/kg) in the presence and absence of fluvastatin (0.6 and 2.0 mg/kg). Compared with the control given diltiazem alone, the Cmax and AUC of diltiazem increased by 30-70% in rats with the concurrent use of fluvastatin, while there was no significant change in Tmax and the plasma half-life (T1/2) of diltiazem. Consequently, absolute and relative bioavailability values of diltiazem in the presence of fluvastatin were significantly higher (p <0.05) than those from the control group, implying that fluvastatin could reduce the presystemic extraction of diltiazem. In conclusion, the concurrent use of fluvastatin significantly enhanced the oral exposure of diltiazem in rats.

Original languageEnglish
Pages (from-to)437-441
Number of pages5
JournalBiopharmaceutics and Drug Disposition
Volume27
Issue number9
DOIs
StatePublished - Dec 2006

Keywords

  • Diltiazem
  • Drug interaction
  • Fluvastatin
  • Pharmacokinetics
  • Rat

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