Phthalates Exposure and Attention-Deficit/Hyperactivity Disorder in School-Age Children

Bung Nyun Kim; Soo Churl Cho; Yeni Kim; Min Sup Shin; Hee Jeong Yoo; Jae Won Kim; Young Hee Yang; Hyo Won Kim; Soo Young Bhang; Yun Chul Hong

doi:10.1016/j.biopsych.2009.07.034

Phthalates Exposure and Attention-Deficit/Hyperactivity Disorder in School-Age Children

Bung Nyun Kim
, Soo Churl Cho
, Yeni Kim
, Min Sup Shin
, Hee Jeong Yoo
, Jae Won Kim
, Young Hee Yang
, Hyo Won Kim
, Soo Young Bhang
, Yun Chul Hong

Department of Medicine

Research output: Contribution to journal › Article › peer-review

221 Scopus citations

Abstract

Background: Very few studies have examined the association between attention-deficit/hyperactivity disorder (ADHD) and phthalate exposure in humans. The aim of this study was to investigate the impact of phthalates on symptoms of ADHD in school-age children. Methods: A cross-sectional examination of urine phthalate concentrations was performed, and scores on measures of ADHD symptoms and neuropsychological dysfunction with regard to attention and impulsivity were obtained from 261 Korean children, age 8-11 years. Results: Mono-2-ethylheyl phthalate (MEHP) and mono-2-ethyl-5-oxohexylphthalate (MEOP) for metabolites of Di-2-ethylhexylphthalate (DEHP) and mono-n-butyl phthalate (MNBP) for metabolites of dibutyl phthalate (DBP) were measured in urine samples. The mean concentrations of MEHP, MEOP, and MNBP were 34.0 μg/dL (SD = 36.3; range: 2.1-386.7), 23.4 μg/dL (SD = 23.0; range: .75-244.8), and 46.7 μg/L (SD = 21.4; range: 13.2-159.3), respectively. After adjustment for covariates, teacher-rated ADHD scores were significantly associated with DEHP metabolites but not with DBP metabolites. We also found significant relationships between the urine concentrations of metabolites for DBP and the number of omission and commission errors in continuous performance tests (CPT) after adjustment for covariates. Conclusion: The present study showed a strong positive association between phthalate metabolites in urine and symptoms of ADHD among school-age children.

Original language	English
Pages (from-to)	958-963
Number of pages	6
Journal	Biological Psychiatry
Volume	66
Issue number	10
DOIs	https://doi.org/10.1016/j.biopsych.2009.07.034
State	Published - 15 Nov 2009

Keywords

ADHD
neuropsychology
phthalate

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10.1016/j.biopsych.2009.07.034

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title = "Phthalates Exposure and Attention-Deficit/Hyperactivity Disorder in School-Age Children",

abstract = "Background: Very few studies have examined the association between attention-deficit/hyperactivity disorder (ADHD) and phthalate exposure in humans. The aim of this study was to investigate the impact of phthalates on symptoms of ADHD in school-age children. Methods: A cross-sectional examination of urine phthalate concentrations was performed, and scores on measures of ADHD symptoms and neuropsychological dysfunction with regard to attention and impulsivity were obtained from 261 Korean children, age 8-11 years. Results: Mono-2-ethylheyl phthalate (MEHP) and mono-2-ethyl-5-oxohexylphthalate (MEOP) for metabolites of Di-2-ethylhexylphthalate (DEHP) and mono-n-butyl phthalate (MNBP) for metabolites of dibutyl phthalate (DBP) were measured in urine samples. The mean concentrations of MEHP, MEOP, and MNBP were 34.0 μg/dL (SD = 36.3; range: 2.1-386.7), 23.4 μg/dL (SD = 23.0; range: .75-244.8), and 46.7 μg/L (SD = 21.4; range: 13.2-159.3), respectively. After adjustment for covariates, teacher-rated ADHD scores were significantly associated with DEHP metabolites but not with DBP metabolites. We also found significant relationships between the urine concentrations of metabolites for DBP and the number of omission and commission errors in continuous performance tests (CPT) after adjustment for covariates. Conclusion: The present study showed a strong positive association between phthalate metabolites in urine and symptoms of ADHD among school-age children.",

keywords = "ADHD, neuropsychology, phthalate",

author = "Kim, \{Bung Nyun\} and Cho, \{Soo Churl\} and Yeni Kim and Shin, \{Min Sup\} and Yoo, \{Hee Jeong\} and Kim, \{Jae Won\} and Yang, \{Young Hee\} and Kim, \{Hyo Won\} and Bhang, \{Soo Young\} and Hong, \{Yun Chul\}",

year = "2009",

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doi = "10.1016/j.biopsych.2009.07.034",

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journal = "Biological Psychiatry",

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T1 - Phthalates Exposure and Attention-Deficit/Hyperactivity Disorder in School-Age Children

AU - Kim, Bung Nyun

AU - Cho, Soo Churl

AU - Kim, Yeni

AU - Shin, Min Sup

AU - Yoo, Hee Jeong

AU - Kim, Jae Won

AU - Yang, Young Hee

AU - Kim, Hyo Won

AU - Bhang, Soo Young

AU - Hong, Yun Chul

PY - 2009/11/15

Y1 - 2009/11/15

N2 - Background: Very few studies have examined the association between attention-deficit/hyperactivity disorder (ADHD) and phthalate exposure in humans. The aim of this study was to investigate the impact of phthalates on symptoms of ADHD in school-age children. Methods: A cross-sectional examination of urine phthalate concentrations was performed, and scores on measures of ADHD symptoms and neuropsychological dysfunction with regard to attention and impulsivity were obtained from 261 Korean children, age 8-11 years. Results: Mono-2-ethylheyl phthalate (MEHP) and mono-2-ethyl-5-oxohexylphthalate (MEOP) for metabolites of Di-2-ethylhexylphthalate (DEHP) and mono-n-butyl phthalate (MNBP) for metabolites of dibutyl phthalate (DBP) were measured in urine samples. The mean concentrations of MEHP, MEOP, and MNBP were 34.0 μg/dL (SD = 36.3; range: 2.1-386.7), 23.4 μg/dL (SD = 23.0; range: .75-244.8), and 46.7 μg/L (SD = 21.4; range: 13.2-159.3), respectively. After adjustment for covariates, teacher-rated ADHD scores were significantly associated with DEHP metabolites but not with DBP metabolites. We also found significant relationships between the urine concentrations of metabolites for DBP and the number of omission and commission errors in continuous performance tests (CPT) after adjustment for covariates. Conclusion: The present study showed a strong positive association between phthalate metabolites in urine and symptoms of ADHD among school-age children.

AB - Background: Very few studies have examined the association between attention-deficit/hyperactivity disorder (ADHD) and phthalate exposure in humans. The aim of this study was to investigate the impact of phthalates on symptoms of ADHD in school-age children. Methods: A cross-sectional examination of urine phthalate concentrations was performed, and scores on measures of ADHD symptoms and neuropsychological dysfunction with regard to attention and impulsivity were obtained from 261 Korean children, age 8-11 years. Results: Mono-2-ethylheyl phthalate (MEHP) and mono-2-ethyl-5-oxohexylphthalate (MEOP) for metabolites of Di-2-ethylhexylphthalate (DEHP) and mono-n-butyl phthalate (MNBP) for metabolites of dibutyl phthalate (DBP) were measured in urine samples. The mean concentrations of MEHP, MEOP, and MNBP were 34.0 μg/dL (SD = 36.3; range: 2.1-386.7), 23.4 μg/dL (SD = 23.0; range: .75-244.8), and 46.7 μg/L (SD = 21.4; range: 13.2-159.3), respectively. After adjustment for covariates, teacher-rated ADHD scores were significantly associated with DEHP metabolites but not with DBP metabolites. We also found significant relationships between the urine concentrations of metabolites for DBP and the number of omission and commission errors in continuous performance tests (CPT) after adjustment for covariates. Conclusion: The present study showed a strong positive association between phthalate metabolites in urine and symptoms of ADHD among school-age children.

KW - ADHD

KW - neuropsychology

KW - phthalate

UR - https://www.scopus.com/pages/publications/70350573469

U2 - 10.1016/j.biopsych.2009.07.034

DO - 10.1016/j.biopsych.2009.07.034

M3 - Article

C2 - 19748073

AN - SCOPUS:70350573469

SN - 0006-3223

VL - 66

SP - 958

EP - 963

JO - Biological Psychiatry

JF - Biological Psychiatry

IS - 10

ER -

Phthalates Exposure and Attention-Deficit/Hyperactivity Disorder in School-Age Children

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