Phytochemical profiling and bioactivity of a mangrove plant, Sonneratia apetala, from Odisha Coast of India

Jayanta Kumar Patra, Swagat Kumar Das, Hrudayanath Thatoi

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Objective: To test the antioxidant, antidiabetic, anticancer and antibacterial activities along with phytochemicals of Sonneratia apetala Buch.-Ham. Methods: The antibacterial activity was determined by agar well diffusion method. The antioxidant activity was determined by standard assay. The antidiabetic activity was evaluated by α-glucosidase inhibition assay and in vivo anticancer property was determined against Ehrlich ascites carcinoma (EAC) cells in Swiss Albino mice. Further partial characterization of the methanol extracts was carried out by thin layer chromatography, high performance liquid chromatography, 1H nuclear magnetic resonance spectroscopy and Fourier transform-infra red spectrum spectral analysis. Results: Four solvent extracts (acetone, ethanol, methanol and aqueous) of leaf and bark possess strong antioxidant properties. In vivo anticancer activity of methanol extract leaf indicated positive activity showing 34% inhibition against EAC cells in Swiss Albino mice. All extracts exhibited α-glucosidase inhibitory activity in a dose-dependent manner indicating presence of promising antidiabetic properties. The extracts possess strong antibacterial activity against the selected pathogenic bacteria (minimal inhibitory concentration ranging from 1.25–5.00 mg/mL). The partial characterization of the methanol extracts of leaf and bark revealed the presence of phenolics as the lead compound responsible for studied bioactivities of the plant extracts. Conclusion: Sonneratia apetala extracts have potent antibacterial, antioxidant, antidiabetic and anticancer properties which can be further exploited for its pharmaceutical applications.

Original languageEnglish
Pages (from-to)274-285
Number of pages12
JournalChinese Journal of Integrative Medicine
Volume21
Issue number4
DOIs
StatePublished - 1 Apr 2015

Keywords

  • bioactive compounds
  • chromatography
  • Ehrlich ascites carcinoma
  • mangrove
  • Sonneratia apetala

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