TY - JOUR
T1 - Phytoextract-mediated synthesis of Cu doped NiO nanoparticle using cullon tomentosum plant extract with efficient antibacterial and anticancer property
AU - Indumathi, T.
AU - Hirad, Abdurahman Hajinur
AU - Alarfaj, Abdullah A.
AU - Ranjith Kumar, E.
AU - Chandrasekaran, Karthikeyan
N1 - Publisher Copyright:
© 2023
PY - 2023/10/1
Y1 - 2023/10/1
N2 - In the present study, nickel oxide (NiO) and copper-doped nickel oxide (NiCuO) nanoparticles (NPs) were successfully synthesized using Cullen tomentosum plant extract with the co-precipitation method. This work focuses on the Phyto-mediated synthesis and characterization of NPs for their biological applications. Phytochemicals that exist in the plant extract acts as reducing and capping agent. The successful formation of the NPs was validated by various analysis as XRD, FESEM, EDAX, FT-IR, UV–Vis, and Photoluminescence. According to XRD studies, the average crystallite size of NiO and NiCuO NPs is 36 nm and 31 nm, respectively. The river stone and nanoflower like morphology for NiO and NiCuO NPs are confirmed by FESEM image. Furthermore, the synthesized NPs were tested against Gram-positive (Bacillus subtilis, Streptococcus pneumoniae) and Gram-negative (Klebsiella pneumoniae, Escherichia coli) bacteria, which showed enhanced antibacterial activity of NiCuO NPs. The cytotoxicity of NPs was investigated against human breast cancer cells (MDA-MB-231) and fibroblast L929 cell lines. Also, the IC50 value for human breast cancer cells is 11.8 μg/mL. According to these findings, NiCuO NPs are potential nanomaterials with advanced healthcare uses.
AB - In the present study, nickel oxide (NiO) and copper-doped nickel oxide (NiCuO) nanoparticles (NPs) were successfully synthesized using Cullen tomentosum plant extract with the co-precipitation method. This work focuses on the Phyto-mediated synthesis and characterization of NPs for their biological applications. Phytochemicals that exist in the plant extract acts as reducing and capping agent. The successful formation of the NPs was validated by various analysis as XRD, FESEM, EDAX, FT-IR, UV–Vis, and Photoluminescence. According to XRD studies, the average crystallite size of NiO and NiCuO NPs is 36 nm and 31 nm, respectively. The river stone and nanoflower like morphology for NiO and NiCuO NPs are confirmed by FESEM image. Furthermore, the synthesized NPs were tested against Gram-positive (Bacillus subtilis, Streptococcus pneumoniae) and Gram-negative (Klebsiella pneumoniae, Escherichia coli) bacteria, which showed enhanced antibacterial activity of NiCuO NPs. The cytotoxicity of NPs was investigated against human breast cancer cells (MDA-MB-231) and fibroblast L929 cell lines. Also, the IC50 value for human breast cancer cells is 11.8 μg/mL. According to these findings, NiCuO NPs are potential nanomaterials with advanced healthcare uses.
KW - Antibacterial activity
KW - Anticancer activity
KW - Cullon tomentosum
KW - Cu–NiO NPs
KW - Green synthesis
UR - http://www.scopus.com/inward/record.url?scp=85166251425&partnerID=8YFLogxK
U2 - 10.1016/j.ceramint.2023.07.142
DO - 10.1016/j.ceramint.2023.07.142
M3 - Article
AN - SCOPUS:85166251425
SN - 0272-8842
VL - 49
SP - 31829
EP - 31838
JO - Ceramics International
JF - Ceramics International
IS - 19
ER -