Plants of the genus Vitis: Phenolic compounds, anticancer properties and clinical relevance

Bahare Salehi; S. Vlaisavljevic; Charles Oluwaseun Adetunji; Juliana Bunmi Adetunji; Dorota Kregiel; Hubert Antolak; Ewelina Pawlikowska; Y. Uprety; Ksenija S. Mileski; Hari Prasad Devkota; J. Sharifi-Rad; Gitishree Das; Jayanta Kumar Patra; Arun Kumar Jugran; Antonio Segura-Carretero; María del Mar Contreras

doi:10.1016/j.tifs.2019.07.042

Plants of the genus Vitis: Phenolic compounds, anticancer properties and clinical relevance

Bahare Salehi, S. Vlaisavljevic, Charles Oluwaseun Adetunji, Juliana Bunmi Adetunji, Dorota Kregiel, Hubert Antolak, Ewelina Pawlikowska, Y. Uprety, Ksenija S. Mileski, Hari Prasad Devkota, J. Sharifi-Rad, Gitishree Das, Jayanta Kumar Patra, Arun Kumar Jugran, Antonio Segura-Carretero, María del Mar Contreras

Research Institute of Integrative Life Sciences

Research output: Contribution to journal › Review article › peer-review

74 Scopus citations

Abstract

Background: Vitis genus comprised about 70 species. Concerning its pharmacological properties, V. vinifera is the most studied one, but there are other species with interest. Scope and approach: Therefore, this review aims to provide an updated overview on bioactive phytochemicals present in food products (grapes and wine) of V. vinifera and other Vitis species, as well as in different underused bioresources (stem, leaves, seeds, wine pomace, etc.). Moreover, due to their promising perspectives in the field of anticancer drug discovery, this bioactivity has been covered as well as the contribution that Vitis phenolic compounds has. Findings and conclusions: Among the plant products reviewed, grape seed extracts was the most investigated at preclinical phase, hence exhibiting a promising potential as anticancer drugs. However, an evidence-based clinical efficacy is still lacking.

Original language	English
Pages (from-to)	362-379
Number of pages	18
Journal	Trends in Food Science and Technology
Volume	91
DOIs	https://doi.org/10.1016/j.tifs.2019.07.042
State	Published - Sep 2019

Keywords

Anticancer
Phenolic compounds
Proanthocyanidinds
Resveratrol
Vitis

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Salehi, B., Vlaisavljevic, S., Adetunji, C. O., Adetunji, J. B., Kregiel, D., Antolak, H., Pawlikowska, E., Uprety, Y., Mileski, K. S., Devkota, H. P., Sharifi-Rad, J., Das, G., Patra, J. K., Jugran, A. K., Segura-Carretero, A., & Contreras, M. D. M. (2019). Plants of the genus Vitis: Phenolic compounds, anticancer properties and clinical relevance. Trends in Food Science and Technology, 91, 362-379. https://doi.org/10.1016/j.tifs.2019.07.042

@article{993c8203013b46f2b856e410008705dd,

title = "Plants of the genus Vitis: Phenolic compounds, anticancer properties and clinical relevance",

abstract = "Background: Vitis genus comprised about 70 species. Concerning its pharmacological properties, V. vinifera is the most studied one, but there are other species with interest. Scope and approach: Therefore, this review aims to provide an updated overview on bioactive phytochemicals present in food products (grapes and wine) of V. vinifera and other Vitis species, as well as in different underused bioresources (stem, leaves, seeds, wine pomace, etc.). Moreover, due to their promising perspectives in the field of anticancer drug discovery, this bioactivity has been covered as well as the contribution that Vitis phenolic compounds has. Findings and conclusions: Among the plant products reviewed, grape seed extracts was the most investigated at preclinical phase, hence exhibiting a promising potential as anticancer drugs. However, an evidence-based clinical efficacy is still lacking.",

keywords = "Anticancer, Phenolic compounds, Proanthocyanidinds, Resveratrol, Vitis",

author = "Bahare Salehi and S. Vlaisavljevic and Adetunji, {Charles Oluwaseun} and Adetunji, {Juliana Bunmi} and Dorota Kregiel and Hubert Antolak and Ewelina Pawlikowska and Y. Uprety and Mileski, {Ksenija S.} and Devkota, {Hari Prasad} and J. Sharifi-Rad and Gitishree Das and Patra, {Jayanta Kumar} and Jugran, {Arun Kumar} and Antonio Segura-Carretero and Contreras, {Mar{\'i}a del Mar}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2019",

month = sep,

doi = "10.1016/j.tifs.2019.07.042",

language = "English",

volume = "91",

pages = "362--379",

journal = "Trends in Food Science and Technology",

issn = "0924-2244",

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Salehi, B, Vlaisavljevic, S, Adetunji, CO, Adetunji, JB, Kregiel, D, Antolak, H, Pawlikowska, E, Uprety, Y, Mileski, KS, Devkota, HP, Sharifi-Rad, J, Das, G , Patra, JK, Jugran, AK, Segura-Carretero, A & Contreras, MDM 2019, 'Plants of the genus Vitis: Phenolic compounds, anticancer properties and clinical relevance', Trends in Food Science and Technology, vol. 91, pp. 362-379. https://doi.org/10.1016/j.tifs.2019.07.042

TY - JOUR

T1 - Plants of the genus Vitis

T2 - Phenolic compounds, anticancer properties and clinical relevance

AU - Salehi, Bahare

AU - Vlaisavljevic, S.

AU - Adetunji, Charles Oluwaseun

AU - Adetunji, Juliana Bunmi

AU - Kregiel, Dorota

AU - Antolak, Hubert

AU - Pawlikowska, Ewelina

AU - Uprety, Y.

AU - Mileski, Ksenija S.

AU - Devkota, Hari Prasad

AU - Sharifi-Rad, J.

AU - Das, Gitishree

AU - Patra, Jayanta Kumar

AU - Jugran, Arun Kumar

AU - Segura-Carretero, Antonio

AU - Contreras, María del Mar

PY - 2019/9

Y1 - 2019/9

N2 - Background: Vitis genus comprised about 70 species. Concerning its pharmacological properties, V. vinifera is the most studied one, but there are other species with interest. Scope and approach: Therefore, this review aims to provide an updated overview on bioactive phytochemicals present in food products (grapes and wine) of V. vinifera and other Vitis species, as well as in different underused bioresources (stem, leaves, seeds, wine pomace, etc.). Moreover, due to their promising perspectives in the field of anticancer drug discovery, this bioactivity has been covered as well as the contribution that Vitis phenolic compounds has. Findings and conclusions: Among the plant products reviewed, grape seed extracts was the most investigated at preclinical phase, hence exhibiting a promising potential as anticancer drugs. However, an evidence-based clinical efficacy is still lacking.

AB - Background: Vitis genus comprised about 70 species. Concerning its pharmacological properties, V. vinifera is the most studied one, but there are other species with interest. Scope and approach: Therefore, this review aims to provide an updated overview on bioactive phytochemicals present in food products (grapes and wine) of V. vinifera and other Vitis species, as well as in different underused bioresources (stem, leaves, seeds, wine pomace, etc.). Moreover, due to their promising perspectives in the field of anticancer drug discovery, this bioactivity has been covered as well as the contribution that Vitis phenolic compounds has. Findings and conclusions: Among the plant products reviewed, grape seed extracts was the most investigated at preclinical phase, hence exhibiting a promising potential as anticancer drugs. However, an evidence-based clinical efficacy is still lacking.

KW - Anticancer

KW - Phenolic compounds

KW - Proanthocyanidinds

KW - Resveratrol

KW - Vitis

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U2 - 10.1016/j.tifs.2019.07.042

DO - 10.1016/j.tifs.2019.07.042

M3 - Review article

AN - SCOPUS:85069917222

SN - 0924-2244

VL - 91

SP - 362

EP - 379

JO - Trends in Food Science and Technology

JF - Trends in Food Science and Technology

ER -

Plants of the genus Vitis: Phenolic compounds, anticancer properties and clinical relevance

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Keywords

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