Plasmonic sensors for applications in liquid biopsies

A liquid biopsy is a non-invasive means of gaining insights into the dynamics of disease using a patient's body fluids of patients. It has recently attracted much interest in cancer diagnosis and prognosis. Unlike a conventional tissue biopsy, a liquid biopsy provides a snapshot of the disease from the primary diagnosis along with recognizing distant tumor locations. Additionally, liquid biopsies can be used for repeated sampling of tumor markers and can be adjusted depending on the patient's response to personalized treatment. Among the various techniques developed for liquid biopsies, the nanoplasmonic biosensor presents a promising approach due to its high sensitivity and selectivity, as well as multiplexing capability for simultaneous target detection. This chapter will focus on emerging technologies for the detection of various disease markers using nanoplasmonic biosensors.