Abstract
Carbon fiber (CNF), prepared by carbonization of electrospun polyacrylonitrile (PAN) fibers, is systematically investigated as a mediator to replace conventional organic matrices for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-MS). CNF exhibits a high salt tolerance, sensitivity, and resolution for organic matrix-free laser desorption/ionization time-of-flight mass spectrometry (LDI-MS) analysis of various analytes under both positive and negative ionization modes. Especially, saccharides, a neutral molecule having low negative ionization efficiency, are successfully detected with CNF. Taken together, this study clearly demonstrates CNF is a promising material to develop an efficient and universal platform for LDI-MS analysis regardless of preferential ionization modes of analytes. [Figure not available: see fulltext.].
Original language | English |
---|---|
Pages (from-to) | 1193-1202 |
Number of pages | 10 |
Journal | Analytical and Bioanalytical Chemistry |
Volume | 413 |
Issue number | 4 |
DOIs | |
State | Published - Feb 2021 |
Keywords
- Carbon nanofiber
- Carbonization
- Laser desorption/ionization
- Mass spectrometry
- Saccharide