Polyacrylonitrile-based carbon nanofibers as a matrix for laser desorption/ionization time-of-flight mass spectrometric analysis of small molecules under both positive and negative ionization modes

Ari Chae, Gwanwon Lee, Dong Yeun Koh, Cheol Min Yang, Sungho Lee, Young Kwan Kim

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Carbon fiber (CNF), prepared by carbonization of electrospun polyacrylonitrile (PAN) fibers, is systematically investigated as a mediator to replace conventional organic matrices for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-MS). CNF exhibits a high salt tolerance, sensitivity, and resolution for organic matrix-free laser desorption/ionization time-of-flight mass spectrometry (LDI-MS) analysis of various analytes under both positive and negative ionization modes. Especially, saccharides, a neutral molecule having low negative ionization efficiency, are successfully detected with CNF. Taken together, this study clearly demonstrates CNF is a promising material to develop an efficient and universal platform for LDI-MS analysis regardless of preferential ionization modes of analytes. [Figure not available: see fulltext.].

Original languageEnglish
Pages (from-to)1193-1202
Number of pages10
JournalAnalytical and Bioanalytical Chemistry
Volume413
Issue number4
DOIs
StatePublished - Feb 2021

Keywords

  • Carbon nanofiber
  • Carbonization
  • Laser desorption/ionization
  • Mass spectrometry
  • Saccharide

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