TY - JOUR
T1 - Polycations and their biomedical applications
AU - Kim, Kyobum
AU - Chen, William C.W.
AU - Heo, Yunhoe
AU - Wang, Yadong
N1 - Publisher Copyright:
© 2016
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Polycations are useful delivery vehicles for nucleic acids and proteins. Physicochemical properties, safety, and cost are important design parameters for polycation-enabled controlled release methods. Improvements in the design and biocompatibility of synthetic polycations and complexes thereof are necessary for clinical applications. This review focuses on breakthroughs in the development of biocompatible polycations and their biomedical applications in the past 10 years. First, we summarize current strategies to develop naturally derived and synthetic polycations and describe the most commonly used polycations. Second, we discuss polycation-mediated non-viral gene delivery systems used for tissue engineering and regenerative medicine. Third, we review the development of polycation-mediated self-assembled systems for the delivery of heparin-binding proteins, with an emphasis on translational potential. Finally, we introduce platforms for fabricating polycation-based complexes, including layer-by-layer assembly, polymeric vesicles, polycation-containing microspheres, and approaches to improve the functionality of delivery complexes. With improvements in polycation design, safety, and efficacy, polycation-based controlled delivery is expected to contribute significantly to tissue repair and regeneration applications.
AB - Polycations are useful delivery vehicles for nucleic acids and proteins. Physicochemical properties, safety, and cost are important design parameters for polycation-enabled controlled release methods. Improvements in the design and biocompatibility of synthetic polycations and complexes thereof are necessary for clinical applications. This review focuses on breakthroughs in the development of biocompatible polycations and their biomedical applications in the past 10 years. First, we summarize current strategies to develop naturally derived and synthetic polycations and describe the most commonly used polycations. Second, we discuss polycation-mediated non-viral gene delivery systems used for tissue engineering and regenerative medicine. Third, we review the development of polycation-mediated self-assembled systems for the delivery of heparin-binding proteins, with an emphasis on translational potential. Finally, we introduce platforms for fabricating polycation-based complexes, including layer-by-layer assembly, polymeric vesicles, polycation-containing microspheres, and approaches to improve the functionality of delivery complexes. With improvements in polycation design, safety, and efficacy, polycation-based controlled delivery is expected to contribute significantly to tissue repair and regeneration applications.
KW - Coacervate
KW - Gene therapy
KW - Growth factor delivery
KW - Polycation
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=84984791447&partnerID=8YFLogxK
U2 - 10.1016/j.progpolymsci.2016.05.004
DO - 10.1016/j.progpolymsci.2016.05.004
M3 - Review article
AN - SCOPUS:84984791447
SN - 0079-6700
VL - 60
SP - 18
EP - 50
JO - Progress in Polymer Science
JF - Progress in Polymer Science
ER -