Polycystic ovary syndrome is not associated with polymorphisms of the TCF7L2, CDKAL1, HHEX, KCNJ11, FTO and SLC30A8 genes

Jin Ju Kim, Young Min Choi, Young Min Cho, Min A. Hong, Soo Jin Chae, Kyu Ri Hwang, Seung Sik Hwang, Sang Ho Yoon, Shin Yong Moon

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Objective Insulin resistance is a core feature of polycystic ovary syndrome (PCOS). Recently, genome-wide association studies have reported a number of single-nucleotide polymorphisms (SNPs) with reproducible associations and susceptibilities to type 2 diabetes. We examined the potential association between the diabetogenic genes uncovered in the genome-wide association studies and PCOS in Korean women. Design Case-control study. Patients Women with or without PCOS. Measurements DNA samples from 377 patients with PCOS and 386 age-matched controls were genotyped. Results None of the 12 SNPs in the six genes (KCNJ11, TCF7L2, SLC30A8, HHEX, FTO and CDKAL1) uncovered in the genome-wide association studies were associated with PCOS. For further analysis, the patients with PCOS were divided into two or three subgroups according to genotype, and the associations between the genotypes and insulin resistance or insulin secretory capacity were assessed. No SNPs were significantly associated with HOMA-IR, HOMA βcell (%), or 2-h 75-g oral glucose tolerance test insulin levels in the patients with PCOS; there were no significant associations with other serum hormonal and metabolic markers, such as androgen or glucose levels. Conclusions Our results suggest that the six type 2 diabetes-associated genes identified in genome-wide association studies are not associated with PCOS.

Original languageEnglish
Pages (from-to)439-445
Number of pages7
JournalClinical Endocrinology
Volume77
Issue number3
DOIs
StatePublished - Sep 2012

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