Poly(norepinephrine): Ultrasmooth material-independent surface chemistry and nanodepot for nitric oxide

Seonki Hong; Jihoon Kim; Yun Suk Na; Junghong Park; Sunjin Kim; Kaushik Singha; Gun Il Im; Dong Keun Han; Won Jong Kim; Haeshin Lee

doi:10.1002/anie.201301646

Poly(norepinephrine): Ultrasmooth material-independent surface chemistry and nanodepot for nitric oxide

Seonki Hong, Jihoon Kim, Yun Suk Na, Junghong Park, Sunjin Kim, Kaushik Singha, Gun Il Im, Dong Keun Han, Won Jong Kim, Haeshin Lee

Department of Medicine

Research output: Contribution to journal › Article › peer-review

225 Scopus citations

Abstract

Capture and release: The material-independent surface chemistry of a poly(norepinephrine) (pNE) which exhibits perfect smoothness at the nanometer scale is controlled by 3,4-dihydroxybenzaldehyde-norepinephrine (DHBA-NE) conjugates. The pNE layer containing DHBA-NE serves to store and release small therapeutics such as nitric oxide.

Original language	English
Pages (from-to)	9187-9191
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	35
DOIs	https://doi.org/10.1002/anie.201301646
State	Published - 26 Aug 2013

Keywords

bioinspired chemistry
drug delivery
nitric oxide
polymers
surface chemistry

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10.1002/anie.201301646

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abstract = "Capture and release: The material-independent surface chemistry of a poly(norepinephrine) (pNE) which exhibits perfect smoothness at the nanometer scale is controlled by 3,4-dihydroxybenzaldehyde-norepinephrine (DHBA-NE) conjugates. The pNE layer containing DHBA-NE serves to store and release small therapeutics such as nitric oxide.",

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AU - Park, Junghong

AU - Kim, Sunjin

AU - Singha, Kaushik

AU - Im, Gun Il

AU - Han, Dong Keun

AU - Kim, Won Jong

AU - Lee, Haeshin

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KW - drug delivery

KW - nitric oxide

KW - polymers

KW - surface chemistry

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Poly(norepinephrine): Ultrasmooth material-independent surface chemistry and nanodepot for nitric oxide

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Keywords

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