Poor Prognosis of Lower Inner Quadrant in Lymph Node–negative Breast Cancer Patients Who Received No Chemotherapy: A Study Based on Nationwide Korean Breast Cancer Registry Database

Ki Tae Hwang; Jongjin Kim; Eun Kyu Kim; Sung Hoo Jung; Guiyun Sohn; Seung Il Kim; Joon Jeong; Hyouk Jin Lee; Jin Hyun Park; Sohee Oh; Sei Hyun Ahn; Dong Young Noh; Seok Jin Nam; Eun Sook Lee; Byeong Woo Park; Woo Chul Noh; Jung Han Yoon; Soo Jung Lee; Eun Kyu Lee; Joon Jeong; Sehwan Han; Ho Yong Park; Nam Sun Paik; Young Tae Bae; Hyouk Jin Lee; Heung Kyu Park; Seung Sang Ko; Byung Joo Song; Young Jin Suh; Sung Hoo Jung; Se Heon Cho; Sei Joong Kim; Se Jeong Oh; Byung Kyun Ko; Ku Sang Kim; Chanheun Park; Jong Min Baek; Ki Tae Hwang; Il Sung Chang; Jeoung Won Bae; Jeong Soo Kim; Sun Hee Kang; Geumhee Gwak; Jee Hyun Lee; Tae Hyun Kim; Myungchul Chang; Sung Yong Kim; Jung Sun Lee; Jeong Yoon Song; Hai Lin Park; Sun Young Min; Jung Hyun Yang; Sung Hwan Park; Woo Chan Park; Lee Su Kim; Dong Won Ryu; Kweon Cheon Kim; Min Sung Chung; Hee Boong Park; Cheol Wan Lim; Un Jong Choi; Beom Seok Kwak; Young Sam Park; Hyuk Jai Shin; Young Jin Choi; Doyil Kim; Airi Han; Jong Hyun Koh; Sangyong Choi; Daesung Yoon; Soo Youn Choi; Shin Hee Chul; Jae Il Kim; Jae Hyuck Choi; Jin Woo Ryu; Chang Dae Ko; Il Kyun Lee; Dong Seok Lee; Seunghye Choi; Youn Ki Min; Young San Jeon; Eun Hwa Park

doi:10.1016/j.clbc.2016.12.011

Poor Prognosis of Lower Inner Quadrant in Lymph Node–negative Breast Cancer Patients Who Received No Chemotherapy: A Study Based on Nationwide Korean Breast Cancer Registry Database

Ki Tae Hwang, Jongjin Kim, Eun Kyu Kim, Sung Hoo Jung, Guiyun Sohn, Seung Il Kim, Joon Jeong, Hyouk Jin Lee, Jin Hyun Park, Sohee Oh, Sei Hyun Ahn, Dong Young Noh, Seok Jin Nam, Eun Sook Lee, Byeong Woo Park, Woo Chul Noh, Jung Han Yoon, Soo Jung Lee, Eun Kyu Lee, Joon JeongSehwan Han, Ho Yong Park, Nam Sun Paik, Young Tae Bae, Hyouk Jin Lee, Heung Kyu Park, Seung Sang Ko, Byung Joo Song, Young Jin Suh, Sung Hoo Jung, Se Heon Cho, Sei Joong Kim, Se Jeong Oh, Byung Kyun Ko, Ku Sang Kim, Chanheun Park, Jong Min Baek, Ki Tae Hwang, Il Sung Chang, Jeoung Won Bae, Jeong Soo Kim, Sun Hee Kang, Geumhee Gwak, Jee Hyun Lee, Tae Hyun Kim, Myungchul Chang, Sung Yong Kim, Jung Sun Lee, Jeong Yoon Song, Hai Lin Park, Sun Young Min, Jung Hyun Yang, Sung Hwan Park, Woo Chan Park, Lee Su Kim, Dong Won Ryu, Kweon Cheon Kim, Min Sung Chung, Hee Boong Park, Cheol Wan Lim, Un Jong Choi, Beom Seok Kwak, Young Sam Park, Hyuk Jai Shin, Young Jin Choi, Doyil Kim, Airi Han, Jong Hyun Koh, Sangyong Choi, Daesung Yoon, Soo Youn Choi, Shin Hee Chul, Jae Il Kim, Jae Hyuck Choi, Jin Woo Ryu, Chang Dae Ko, Il Kyun Lee, Dong Seok Lee, Seunghye Choi, Youn Ki Min, Young San Jeon, Eun Hwa Park

Department of Medicine

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The influence of primary tumor site on the prognosis of breast cancer is not consistent but still controversial. We analyzed data of 63,388 patients with primary breast cancer from the Korean Breast Cancer Registry. Lower inner quadrant showed a worse prognosis despite having more favorable clinicopathologic features than other tumor locations and it was more prominent for lymph node–negative patients who received no chemotherapy. Background We aimed to investigate the prognostic influence of primary tumor site on the survival of patients with breast cancer. Patients and Methods Data of 63,388 patients with primary breast cancer from the Korean Breast Cancer Registry were analyzed. Primary tumor sites were classified into 5 groups: upper outer quadrant, lower outer quadrant, upper inner quadrant, lower inner quadrant (LIQ), and central portion. We analyzed overall survival (OS) and breast cancer–specific survival (BCSS) according to primary tumor site. Results Central portion and LIQ showed lower survival rates regarding both OS and BCSS compared with the other 3 quadrants (all P < .05) and hazard ratios were 1.267 (95% CI, 1.180-1.360, P < .001) and 1.215 (95% CI, 1.097-1.345, P < .001), respectively. Although central portion showed more unfavorable clinicopathologic features, LIQ showed more favorable features than the other 3 quadrants. Primary tumor site was a significant factor in univariate and multivariate analyses for OS and BCSS (all P < .001). For lymph node–negative patients, LIQ showed a worse OS than the other primary tumor sites in the subgroup with no chemotherapy (P < .001), but that effect disappeared in the subgroup with chemotherapy (P = .058). Conclusion LIQ showed a worse prognosis despite having more favorable clinicopathologic features than other tumor locations and it was more prominent for lymph node–negative patients who received no chemotherapy. The hypothesis of possible hidden internal mammary node metastasis could be suggested to play a key role in LIQ lesions.

Original language	English
Pages (from-to)	e169-e184
Journal	Clinical Breast Cancer
Volume	17
Issue number	4
DOIs	https://doi.org/10.1016/j.clbc.2016.12.011
State	Published - Jul 2017

Keywords

Primary tumor site
Prognosis
Survival analysis
Tumor location

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.clbc.2016.12.011

Cite this

Hwang, K. T., Kim, J., Kim, E. K., Jung, S. H., Sohn, G., Kim, S. I., Jeong, J., Lee, H. J., Park, J. H., Oh, S., Ahn, S. H., Noh, D. Y., Nam, S. J., Lee, E. S., Park, B. W., Noh, W. C., Yoon, J. H., Lee, S. J., Lee, E. K., ... Park, E. H. (2017). Poor Prognosis of Lower Inner Quadrant in Lymph Node–negative Breast Cancer Patients Who Received No Chemotherapy: A Study Based on Nationwide Korean Breast Cancer Registry Database. Clinical Breast Cancer, 17(4), e169-e184. https://doi.org/10.1016/j.clbc.2016.12.011

@article{5b7b7ca4f96f45518da2af381f7f9dda,

title = "Poor Prognosis of Lower Inner Quadrant in Lymph Node–negative Breast Cancer Patients Who Received No Chemotherapy: A Study Based on Nationwide Korean Breast Cancer Registry Database",

abstract = "The influence of primary tumor site on the prognosis of breast cancer is not consistent but still controversial. We analyzed data of 63,388 patients with primary breast cancer from the Korean Breast Cancer Registry. Lower inner quadrant showed a worse prognosis despite having more favorable clinicopathologic features than other tumor locations and it was more prominent for lymph node–negative patients who received no chemotherapy. Background We aimed to investigate the prognostic influence of primary tumor site on the survival of patients with breast cancer. Patients and Methods Data of 63,388 patients with primary breast cancer from the Korean Breast Cancer Registry were analyzed. Primary tumor sites were classified into 5 groups: upper outer quadrant, lower outer quadrant, upper inner quadrant, lower inner quadrant (LIQ), and central portion. We analyzed overall survival (OS) and breast cancer–specific survival (BCSS) according to primary tumor site. Results Central portion and LIQ showed lower survival rates regarding both OS and BCSS compared with the other 3 quadrants (all P < .05) and hazard ratios were 1.267 (95% CI, 1.180-1.360, P < .001) and 1.215 (95% CI, 1.097-1.345, P < .001), respectively. Although central portion showed more unfavorable clinicopathologic features, LIQ showed more favorable features than the other 3 quadrants. Primary tumor site was a significant factor in univariate and multivariate analyses for OS and BCSS (all P < .001). For lymph node–negative patients, LIQ showed a worse OS than the other primary tumor sites in the subgroup with no chemotherapy (P < .001), but that effect disappeared in the subgroup with chemotherapy (P = .058). Conclusion LIQ showed a worse prognosis despite having more favorable clinicopathologic features than other tumor locations and it was more prominent for lymph node–negative patients who received no chemotherapy. The hypothesis of possible hidden internal mammary node metastasis could be suggested to play a key role in LIQ lesions.",

keywords = "Primary tumor site, Prognosis, Survival analysis, Tumor location",

author = "Hwang, {Ki Tae} and Jongjin Kim and Kim, {Eun Kyu} and Jung, {Sung Hoo} and Guiyun Sohn and Kim, {Seung Il} and Joon Jeong and Lee, {Hyouk Jin} and Park, {Jin Hyun} and Sohee Oh and Ahn, {Sei Hyun} and Noh, {Dong Young} and Nam, {Seok Jin} and Lee, {Eun Sook} and Park, {Byeong Woo} and Noh, {Woo Chul} and Yoon, {Jung Han} and Lee, {Soo Jung} and Lee, {Eun Kyu} and Joon Jeong and Sehwan Han and Park, {Ho Yong} and Paik, {Nam Sun} and Bae, {Young Tae} and Lee, {Hyouk Jin} and Park, {Heung Kyu} and Ko, {Seung Sang} and Song, {Byung Joo} and Suh, {Young Jin} and Jung, {Sung Hoo} and Cho, {Se Heon} and Kim, {Sei Joong} and Oh, {Se Jeong} and Ko, {Byung Kyun} and Kim, {Ku Sang} and Chanheun Park and Baek, {Jong Min} and Hwang, {Ki Tae} and Chang, {Il Sung} and Bae, {Jeoung Won} and Kim, {Jeong Soo} and Kang, {Sun Hee} and Geumhee Gwak and Lee, {Jee Hyun} and Kim, {Tae Hyun} and Myungchul Chang and Kim, {Sung Yong} and Lee, {Jung Sun} and Song, {Jeong Yoon} and Park, {Hai Lin} and Min, {Sun Young} and Yang, {Jung Hyun} and Park, {Sung Hwan} and Park, {Woo Chan} and Kim, {Lee Su} and Ryu, {Dong Won} and Kim, {Kweon Cheon} and Chung, {Min Sung} and Park, {Hee Boong} and Lim, {Cheol Wan} and Choi, {Un Jong} and Kwak, {Beom Seok} and Park, {Young Sam} and Shin, {Hyuk Jai} and Choi, {Young Jin} and Doyil Kim and Airi Han and Koh, {Jong Hyun} and Sangyong Choi and Daesung Yoon and Choi, {Soo Youn} and Chul, {Shin Hee} and Kim, {Jae Il} and Choi, {Jae Hyuck} and Ryu, {Jin Woo} and Ko, {Chang Dae} and Lee, {Il Kyun} and Lee, {Dong Seok} and Seunghye Choi and Min, {Youn Ki} and Jeon, {Young San} and Park, {Eun Hwa}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2017",

month = jul,

doi = "10.1016/j.clbc.2016.12.011",

language = "English",

volume = "17",

pages = "e169--e184",

journal = "Clinical Breast Cancer",

issn = "1526-8209",

publisher = "Elsevier Inc.",

number = "4",

}

Hwang, KT, Kim, J, Kim, EK, Jung, SH, Sohn, G, Kim, SI, Jeong, J, Lee, HJ, Park, JH, Oh, S, Ahn, SH, Noh, DY, Nam, SJ, Lee, ES, Park, BW, Noh, WC, Yoon, JH, Lee, SJ, Lee, EK, Jeong, J, Han, S, Park, HY, Paik, NS, Bae, YT, Lee, HJ, Park, HK, Ko, SS, Song, BJ, Suh, YJ, Jung, SH, Cho, SH, Kim, SJ, Oh, SJ, Ko, BK, Kim, KS, Park, C, Baek, JM, Hwang, KT, Chang, IS, Bae, JW, Kim, JS, Kang, SH, Gwak, G, Lee, JH, Kim, TH, Chang, M, Kim, SY, Lee, JS, Song, JY, Park, HL, Min, SY, Yang, JH, Park, SH, Park, WC, Kim, LS, Ryu, DW, Kim, KC, Chung, MS, Park, HB, Lim, CW, Choi, UJ, Kwak, BS, Park, YS, Shin, HJ, Choi, YJ, Kim, D, Han, A, Koh, JH, Choi, S, Yoon, D, Choi, SY, Chul, SH, Kim, JI, Choi, JH, Ryu, JW, Ko, CD, Lee, IK, Lee, DS, Choi, S, Min, YK, Jeon, YS & Park, EH 2017, 'Poor Prognosis of Lower Inner Quadrant in Lymph Node–negative Breast Cancer Patients Who Received No Chemotherapy: A Study Based on Nationwide Korean Breast Cancer Registry Database', Clinical Breast Cancer, vol. 17, no. 4, pp. e169-e184. https://doi.org/10.1016/j.clbc.2016.12.011

Poor Prognosis of Lower Inner Quadrant in Lymph Node–negative Breast Cancer Patients Who Received No Chemotherapy: A Study Based on Nationwide Korean Breast Cancer Registry Database. / Hwang, Ki Tae; Kim, Jongjin; Kim, Eun Kyu et al.
In: Clinical Breast Cancer, Vol. 17, No. 4, 07.2017, p. e169-e184.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Poor Prognosis of Lower Inner Quadrant in Lymph Node–negative Breast Cancer Patients Who Received No Chemotherapy

T2 - A Study Based on Nationwide Korean Breast Cancer Registry Database

AU - Hwang, Ki Tae

AU - Kim, Jongjin

AU - Kim, Eun Kyu

AU - Jung, Sung Hoo

AU - Sohn, Guiyun

AU - Kim, Seung Il

AU - Jeong, Joon

AU - Lee, Hyouk Jin

AU - Park, Jin Hyun

AU - Oh, Sohee

AU - Ahn, Sei Hyun

AU - Noh, Dong Young

AU - Nam, Seok Jin

AU - Lee, Eun Sook

AU - Park, Byeong Woo

AU - Noh, Woo Chul

AU - Yoon, Jung Han

AU - Lee, Soo Jung

AU - Lee, Eun Kyu

AU - Jeong, Joon

AU - Han, Sehwan

AU - Park, Ho Yong

AU - Paik, Nam Sun

AU - Bae, Young Tae

AU - Lee, Hyouk Jin

AU - Park, Heung Kyu

AU - Ko, Seung Sang

AU - Song, Byung Joo

AU - Suh, Young Jin

AU - Jung, Sung Hoo

AU - Cho, Se Heon

AU - Kim, Sei Joong

AU - Oh, Se Jeong

AU - Ko, Byung Kyun

AU - Kim, Ku Sang

AU - Park, Chanheun

AU - Baek, Jong Min

AU - Hwang, Ki Tae

AU - Chang, Il Sung

AU - Bae, Jeoung Won

AU - Kim, Jeong Soo

AU - Kang, Sun Hee

AU - Gwak, Geumhee

AU - Lee, Jee Hyun

AU - Kim, Tae Hyun

AU - Chang, Myungchul

AU - Kim, Sung Yong

AU - Lee, Jung Sun

AU - Song, Jeong Yoon

AU - Park, Hai Lin

AU - Min, Sun Young

AU - Yang, Jung Hyun

AU - Park, Sung Hwan

AU - Park, Woo Chan

AU - Kim, Lee Su

AU - Ryu, Dong Won

AU - Kim, Kweon Cheon

AU - Chung, Min Sung

AU - Park, Hee Boong

AU - Lim, Cheol Wan

AU - Choi, Un Jong

AU - Kwak, Beom Seok

AU - Park, Young Sam

AU - Shin, Hyuk Jai

AU - Choi, Young Jin

AU - Kim, Doyil

AU - Han, Airi

AU - Koh, Jong Hyun

AU - Choi, Sangyong

AU - Yoon, Daesung

AU - Choi, Soo Youn

AU - Chul, Shin Hee

AU - Kim, Jae Il

AU - Choi, Jae Hyuck

AU - Ryu, Jin Woo

AU - Ko, Chang Dae

AU - Lee, Il Kyun

AU - Lee, Dong Seok

AU - Choi, Seunghye

AU - Min, Youn Ki

AU - Jeon, Young San

AU - Park, Eun Hwa

PY - 2017/7

Y1 - 2017/7

N2 - The influence of primary tumor site on the prognosis of breast cancer is not consistent but still controversial. We analyzed data of 63,388 patients with primary breast cancer from the Korean Breast Cancer Registry. Lower inner quadrant showed a worse prognosis despite having more favorable clinicopathologic features than other tumor locations and it was more prominent for lymph node–negative patients who received no chemotherapy. Background We aimed to investigate the prognostic influence of primary tumor site on the survival of patients with breast cancer. Patients and Methods Data of 63,388 patients with primary breast cancer from the Korean Breast Cancer Registry were analyzed. Primary tumor sites were classified into 5 groups: upper outer quadrant, lower outer quadrant, upper inner quadrant, lower inner quadrant (LIQ), and central portion. We analyzed overall survival (OS) and breast cancer–specific survival (BCSS) according to primary tumor site. Results Central portion and LIQ showed lower survival rates regarding both OS and BCSS compared with the other 3 quadrants (all P < .05) and hazard ratios were 1.267 (95% CI, 1.180-1.360, P < .001) and 1.215 (95% CI, 1.097-1.345, P < .001), respectively. Although central portion showed more unfavorable clinicopathologic features, LIQ showed more favorable features than the other 3 quadrants. Primary tumor site was a significant factor in univariate and multivariate analyses for OS and BCSS (all P < .001). For lymph node–negative patients, LIQ showed a worse OS than the other primary tumor sites in the subgroup with no chemotherapy (P < .001), but that effect disappeared in the subgroup with chemotherapy (P = .058). Conclusion LIQ showed a worse prognosis despite having more favorable clinicopathologic features than other tumor locations and it was more prominent for lymph node–negative patients who received no chemotherapy. The hypothesis of possible hidden internal mammary node metastasis could be suggested to play a key role in LIQ lesions.

AB - The influence of primary tumor site on the prognosis of breast cancer is not consistent but still controversial. We analyzed data of 63,388 patients with primary breast cancer from the Korean Breast Cancer Registry. Lower inner quadrant showed a worse prognosis despite having more favorable clinicopathologic features than other tumor locations and it was more prominent for lymph node–negative patients who received no chemotherapy. Background We aimed to investigate the prognostic influence of primary tumor site on the survival of patients with breast cancer. Patients and Methods Data of 63,388 patients with primary breast cancer from the Korean Breast Cancer Registry were analyzed. Primary tumor sites were classified into 5 groups: upper outer quadrant, lower outer quadrant, upper inner quadrant, lower inner quadrant (LIQ), and central portion. We analyzed overall survival (OS) and breast cancer–specific survival (BCSS) according to primary tumor site. Results Central portion and LIQ showed lower survival rates regarding both OS and BCSS compared with the other 3 quadrants (all P < .05) and hazard ratios were 1.267 (95% CI, 1.180-1.360, P < .001) and 1.215 (95% CI, 1.097-1.345, P < .001), respectively. Although central portion showed more unfavorable clinicopathologic features, LIQ showed more favorable features than the other 3 quadrants. Primary tumor site was a significant factor in univariate and multivariate analyses for OS and BCSS (all P < .001). For lymph node–negative patients, LIQ showed a worse OS than the other primary tumor sites in the subgroup with no chemotherapy (P < .001), but that effect disappeared in the subgroup with chemotherapy (P = .058). Conclusion LIQ showed a worse prognosis despite having more favorable clinicopathologic features than other tumor locations and it was more prominent for lymph node–negative patients who received no chemotherapy. The hypothesis of possible hidden internal mammary node metastasis could be suggested to play a key role in LIQ lesions.

KW - Primary tumor site

KW - Prognosis

KW - Survival analysis

KW - Tumor location

UR - http://www.scopus.com/inward/record.url?scp=85011604973&partnerID=8YFLogxK

U2 - 10.1016/j.clbc.2016.12.011

DO - 10.1016/j.clbc.2016.12.011

M3 - Article

C2 - 28169145

AN - SCOPUS:85011604973

SN - 1526-8209

VL - 17

SP - e169-e184

JO - Clinical Breast Cancer

JF - Clinical Breast Cancer

IS - 4

ER -