Predicting osteoporosis by analyzing fracture risk factors and trabecular microarchitectures of the proximal femur from DXA images

Eun Byeol Jo, Ju Hwan Lee, Sung Yun Park, Sung Min Kim

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

This study aimed to identify the optimal threshold ranges for predicting osteoporosis and osteoporotic fractures by analyzing the correlations between trabecular patterns and fracture risk factors. We selected 85 post-menopausal women as experimental subjects and classified them into 29 normal and 56 osteoporotic groups. We proposed a novel thresholding algorithm that divides the threshold ranges from 0 to 95% based on trabecular bone area and assessed osteoporosis predictability for each range. Evaluation parameters were categorized into morphological parameters (Tb.Area, Sk.Length and fractal dimension) and fracture risk factors (MSCT, LSCT, FNW, TW, FNAL and HAL). Consequently, we found the clinical usefulness of our algorithm for discriminating patients with osteoporosis from those with normal bone. The significances between the morphological parameters and the fracture risk factors improved as bone mineral density decreased. Based on these results, we selected the optimal threshold conditions for predicting osteoporosis and osteoporotic fractures at thresholds of 40-80%.

Original languageEnglish
Title of host publicationAdvanced in Computer Science and Its Applications, CSA 2013
PublisherSpringer Verlag
Pages209-216
Number of pages8
ISBN (Print)9783642416736
DOIs
StatePublished - 2014
Event5th FTRA International Conference on Computer Science and its Applications, CSA 2013 - Danang, Viet Nam
Duration: 18 Dec 201321 Dec 2013

Publication series

NameLecture Notes in Electrical Engineering
Volume279 LNEE
ISSN (Print)1876-1100
ISSN (Electronic)1876-1119

Conference

Conference5th FTRA International Conference on Computer Science and its Applications, CSA 2013
Country/TerritoryViet Nam
CityDanang
Period18/12/1321/12/13

Keywords

  • BMD (Bone Mineral Density)
  • DXA (Dual-energy X-ray Absorptiometry)
  • Osteoporosis
  • Osteoporotic Fracture
  • Threshold
  • Trabecular Bone

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