Predictive role of lung injury prediction score in the development of acute respiratory distress syndrome in korea

Beong Ki Kim, Sua Kim, Chi Young Kim, Yu Jin Kim, Seung Heon Lee, Jae Hyung Cha, Je Hyeong Kim

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Purpose: Early recognition and therapeutic intervention are important in patients at high risk of acute respiratory distress syndrome (ARDS). The lung injury prediction score (LIPS) has been used to predict ARDS development; however, it was developed based on the previous definition of ARDS. We investigated the predictive role of LIPS in ARDS development according to its Berlin definition in the Korean population. Materials and Methods: This was a retrospective study that enrolled adult patients admitted to the intensive care unit (ICU) at a single university-affiliated hospital in Korea from September 1, 2018, to August 31, 2019. LIPS at the time of ICU admission and the development of ARDS were evaluated. Results: Of the 548 enrolled patients, 33 (6.0%) fulfilled the Berlin ARDS definition. The LIPS for non-ARDS and ARDS groups were 4.96±3.05 and 8.53±2.45, respectively (p<0.001); it was significantly associated with ARDS development (odds ratio 1.48, 95% confidence interval, 1.29–1.69; p<0.001). LIPS >6 predicted the development of ARDS with a sensitivity of 84.8% and a specificity of 67.2% [area under the curve (AUC)=0.82]. A modified LIPS model adjusted for age and severity at ICU admission predicted ICU mortality in patients with ARDS (AUC=0.80), but not in those without ARDS (AUC=0.54). Conclusion: LIPS predicted the development of ARDS as diagnosed by the Berlin definition in the Korean population. LIPS pro-vides useful information for managing patients with ARDS.

Original languageEnglish
Pages (from-to)417-423
Number of pages7
JournalYonsei Medical Journal
Volume62
Issue number5
DOIs
StatePublished - May 2021

Keywords

  • Acute lung injury
  • Critical illness
  • Prediction model
  • Respiratory distress syndrome
  • Respiratory insufficiency

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