Abstract
Seven new prenylated flavonoids (1-7) and one new prenylated phenylpropiophenone (8) were isolated from roots and rhizomes of Sophora tonkinensis, along with nine known compounds (9-17). The structures 1-8 were elucidated by spectroscopic data analysis and comparison with reported values. Compounds 8 and 12 (7-methoxyebenosin) showed inhibitory activities against nitric oxide production in lipopolysaccharide-induced RAW264.7 cells, with IC 50 values of 8.1 and 6.2 μM, respectively. They also significantly lowered expression of CSF2, TNF, and IL-1β. Lonchocarpol A (10) and erybraedin D (16) at concentrations of 20 μM downregulated proprotein convertase subtilisin/kexin type 9 (PCSK9) mRNA expression in HepG2 cells. Moreover, erybraedin D (16) inhibited PCSK9 protein synthesis (IC 50 7.8 μM), while simultaneously activating AMP-Activated protein kinase and acetyl-CoA carboxylase.
Original language | English |
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Pages (from-to) | 309-317 |
Number of pages | 9 |
Journal | Journal of Natural Products |
Volume | 82 |
Issue number | 2 |
DOIs | |
State | Published - 22 Feb 2019 |