Prenylated flavonoids from the roots and rhizomes of sophora tonkinensis and their effects on the expression of inflammatory mediators and proprotein convertase subtilisin/kexin type 9

Jongmin Ahn, Young Mi Kim, Hee Sung Chae, Young Hee Choi, Hee Chul Ahn, Hunseung Yoo, Minseok Kang, Jinwoong Kim, Young Won Chin

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39 Scopus citations

Abstract

Seven new prenylated flavonoids (1-7) and one new prenylated phenylpropiophenone (8) were isolated from roots and rhizomes of Sophora tonkinensis, along with nine known compounds (9-17). The structures 1-8 were elucidated by spectroscopic data analysis and comparison with reported values. Compounds 8 and 12 (7-methoxyebenosin) showed inhibitory activities against nitric oxide production in lipopolysaccharide-induced RAW264.7 cells, with IC 50 values of 8.1 and 6.2 μM, respectively. They also significantly lowered expression of CSF2, TNF, and IL-1β. Lonchocarpol A (10) and erybraedin D (16) at concentrations of 20 μM downregulated proprotein convertase subtilisin/kexin type 9 (PCSK9) mRNA expression in HepG2 cells. Moreover, erybraedin D (16) inhibited PCSK9 protein synthesis (IC 50 7.8 μM), while simultaneously activating AMP-Activated protein kinase and acetyl-CoA carboxylase.

Original languageEnglish
Pages (from-to)309-317
Number of pages9
JournalJournal of Natural Products
Volume82
Issue number2
DOIs
StatePublished - 22 Feb 2019

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