Preparation and characterization of bioinert amphiphilic P(VDF-co-CTFE)-g-POEM graft copolymer

Rajkumar Patel; Madhumita Patel; Jung Suk Sung; Jong Hak Kim

doi:10.1080/25740881.2020.1719143

Preparation and characterization of bioinert amphiphilic P(VDF-co-CTFE)-g-POEM graft copolymer

Rajkumar Patel, Madhumita Patel, Jung Suk Sung, Jong Hak Kim

Department of Life Science

Yonsei University

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Hydrophobic poly (vinylidene fluoride-co-chlorotrifluoroethylene) P(VDF-co-CTFE) was used as the polymer backbone to graft poly (oxyethylene methacrylate) (POEM) by atom transfer radical polymerization. Synthesis of graft P(VDF-co-CTFE)-g-POEM copolymer was confirmed by fourier transfer infrared spectroscopy (FTIR) and proton nuclear magnetic resonance (¹H-NMR). The hydrophilicty of grafted membrane increased with increasing ingrafting of POEM as characterized by contact angle measurement. Transmission electronmicroscopy (TEM) study reveals the microphase separated morphology of P(VDF-co-CTFE)-g-POEM copolymer. Adhesion of gram-positive and negative bacteria and mouse embryonic fibroblast (MEF) cell on the membrane surface were observed by SEM that showed the enhancement of bioinert properties with the increase in the POEM grafting. Bioinert properties were further confirmed by protein adsorption behavior.

Original language	English
Pages (from-to)	1077-1087
Number of pages	11
Journal	Polymer-Plastics Technology and Materials
Volume	59
Issue number	10
DOIs	https://doi.org/10.1080/25740881.2020.1719143
State	Published - 2 Jul 2020

Keywords

amphiphilic graft copolymer
ATRP
fouling
protein

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title = "Preparation and characterization of bioinert amphiphilic P(VDF-co-CTFE)-g-POEM graft copolymer",

abstract = "Hydrophobic poly (vinylidene fluoride-co-chlorotrifluoroethylene) P(VDF-co-CTFE) was used as the polymer backbone to graft poly (oxyethylene methacrylate) (POEM) by atom transfer radical polymerization. Synthesis of graft P(VDF-co-CTFE)-g-POEM copolymer was confirmed by fourier transfer infrared spectroscopy (FTIR) and proton nuclear magnetic resonance (1H-NMR). The hydrophilicty of grafted membrane increased with increasing ingrafting of POEM as characterized by contact angle measurement. Transmission electronmicroscopy (TEM) study reveals the microphase separated morphology of P(VDF-co-CTFE)-g-POEM copolymer. Adhesion of gram-positive and negative bacteria and mouse embryonic fibroblast (MEF) cell on the membrane surface were observed by SEM that showed the enhancement of bioinert properties with the increase in the POEM grafting. Bioinert properties were further confirmed by protein adsorption behavior.",

keywords = "amphiphilic graft copolymer, ATRP, fouling, protein",

author = "Rajkumar Patel and Madhumita Patel and Sung, {Jung Suk} and Kim, {Jong Hak}",

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T1 - Preparation and characterization of bioinert amphiphilic P(VDF-co-CTFE)-g-POEM graft copolymer

AU - Patel, Rajkumar

AU - Patel, Madhumita

AU - Sung, Jung Suk

AU - Kim, Jong Hak

PY - 2020/7/2

Y1 - 2020/7/2

N2 - Hydrophobic poly (vinylidene fluoride-co-chlorotrifluoroethylene) P(VDF-co-CTFE) was used as the polymer backbone to graft poly (oxyethylene methacrylate) (POEM) by atom transfer radical polymerization. Synthesis of graft P(VDF-co-CTFE)-g-POEM copolymer was confirmed by fourier transfer infrared spectroscopy (FTIR) and proton nuclear magnetic resonance (1H-NMR). The hydrophilicty of grafted membrane increased with increasing ingrafting of POEM as characterized by contact angle measurement. Transmission electronmicroscopy (TEM) study reveals the microphase separated morphology of P(VDF-co-CTFE)-g-POEM copolymer. Adhesion of gram-positive and negative bacteria and mouse embryonic fibroblast (MEF) cell on the membrane surface were observed by SEM that showed the enhancement of bioinert properties with the increase in the POEM grafting. Bioinert properties were further confirmed by protein adsorption behavior.

AB - Hydrophobic poly (vinylidene fluoride-co-chlorotrifluoroethylene) P(VDF-co-CTFE) was used as the polymer backbone to graft poly (oxyethylene methacrylate) (POEM) by atom transfer radical polymerization. Synthesis of graft P(VDF-co-CTFE)-g-POEM copolymer was confirmed by fourier transfer infrared spectroscopy (FTIR) and proton nuclear magnetic resonance (1H-NMR). The hydrophilicty of grafted membrane increased with increasing ingrafting of POEM as characterized by contact angle measurement. Transmission electronmicroscopy (TEM) study reveals the microphase separated morphology of P(VDF-co-CTFE)-g-POEM copolymer. Adhesion of gram-positive and negative bacteria and mouse embryonic fibroblast (MEF) cell on the membrane surface were observed by SEM that showed the enhancement of bioinert properties with the increase in the POEM grafting. Bioinert properties were further confirmed by protein adsorption behavior.

KW - amphiphilic graft copolymer

KW - ATRP

KW - fouling

KW - protein

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DO - 10.1080/25740881.2020.1719143

M3 - Article

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VL - 59

SP - 1077

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JO - Polymer-Plastics Technology and Materials

JF - Polymer-Plastics Technology and Materials

IS - 10

ER -

Preparation and characterization of bioinert amphiphilic P(VDF-co-CTFE)-g-POEM graft copolymer

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Keywords

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